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TranscriptomicsMapping T cell responses to native and neo- islet antigen epitopes in at risk and type 1 diabetes subjects
Gene expression and T cell receptor profiles from single cells from populations of T cells stimulated with islet autoantigenic peptides. CD4 T cells were stimulated with native (proinsulin, GAD fragments) or neo-antigen epitopes or flu vaccine (Pediacel). Activated cells (identified as CD19- CD3+ C...
ORGANISM(S): Homo sapiens 
2021-05-29 | E-MTAB-10323 | biostudies-arrayexpress
UnknownThe Feasibility of Patient-Specific Circulating Tumor DNA Monitoring throughout Multi-Modality Therapy for Locally Advanced Esophageal and Rectal Cancer: A Potential Biomarker for Early Detection of Subclinical Disease.
Not available
S-EPMC7824834 | biostudies-literature
MetabolomicsGeographic variation of mutagenic exposures in kidney cancer genomes

International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not been identified by conventional epidemiology yet potentially make a substantial contribution to cancer burden1. This pertains to clear cell renal cell carcinoma (ccRCC), fo...

2024-03-26 | MTBLS9394 | MetaboLights
UnknownRole of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma.
Not available
S-EPMC4169410 | biostudies-literature
UnknownCould Postnatal Age-Related Uridine Diphosphate Glucuronic Acid Be a Rate-Limiting Factor in the Metabolism of Morphine During the First Week of Life?
Not available
S-EPMC6656938 | biostudies-literature
UnknownRegional Assessment of Lower limb Amputations in sub-Saharan Africa (RAMPs): a prospective cohort study protocol.
Not available
S-EPMC12496064 | biostudies-literature
ProteomicsA heme-binding domain in a voltage gated porassium channel
Heme-affinity pull-down assays and proteomics of lysates from primary cortical neurons identified and EAG channel, hERG3 (Kv11.3) binds to heme.
ORGANISM(S): Mus musculus (Mouse) 
2020-09-17 | PXD019887 | Pride
Eag channel Ether-a-go-go Heme Waters q-tof Domain 
ProteomicsA rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Sirtuin 6 (SIRT6) is a deacylase and mono-ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in the regulation of aging and metabolism. Targeted sequencing identified a SIRT6 allele containing two linked substitutions (N308K/A313S) as enriched in Ashkenazi Jewis...
ORGANISM(S): Homo sapiens (Human) 
2022-10-21 | PXD035689 | Pride
Lmna Centenarian Longevity Sirt6 Adp-ribosylation Aging 
UnknownDiscovery of a heme-binding domain in a neuronal voltage-gated potassium channel.
Not available
S-EPMC7504924 | biostudies-literature
TranscriptomicsRNA-seq of gonadal adipose tissue from male and female Trim28-WT and Trim28 adipose specific KO mice
Many genes have been implicated in WAT lipid metabolism, including tripartite motif containing 28 (Trim28), a gene proposed to primarily influence adiposity via epigenetic mechanisms in embryonic development. We set out to determine if adipose specific deletion of Trim28 led to changes in adipose ti...
ORGANISM(S): Mus musculus 
2020-11-25 | E-MTAB-9809 | biostudies-arrayexpress
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