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ProteomicsStreptococcus pneumoniae biomarker identification by surface shaving and bottom-up mass spectrometry-based proteomics
In this study, genomics- and proteomics-based approaches were used for the identification of Streptococcus pneumoniae potential biomarkers for diagnostics and prospective targets for treatment. Through a Pan-genome analyses 11 strains from the CCUG demonstrating genetic variability within the speci...
ORGANISM(S): Streptococcus pneumoniae Bacteria 
2025-12-15 | PXD063486 | Pride
Proteomics Surface-shaving Bottom-up mass spectrometry Lpi Biomarkers Streptococcus pneumoniae 
UnknownPatients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial.
Not available
S-EPMC5015426 | biostudies-literature
UnknownDeep learning-based pancreas volume assessment in individuals with type 1 diabetes.
Not available
S-EPMC8734282 | biostudies-literature
ProteomicsThe proteomic responses of carbapenemase-producing and non-producing carbapenem-resistant Pseudomonas aeruginosa strains to subminimal-inhibitory concentrations of meropenem revealed by quantitative tandem mass spectrometry
Pseudomonas aeruginosa is a major opportunistic pathogen causing a wide range of infections and one of the most problematic bacteria regarding antibiotic resistance, with an increasing incidence of multidrug and extensively-drug resistant strains, including resistance to last resource antibiotics su...
ORGANISM(S): Homo sapiens (Human) 
2023-01-05 | PXD034987 | Pride
Multidrug resistance High-risk clones Opportunistic pathogen Antibiotic resistance Tandem mass spectrometry Tandem mass tag (tmt) Quantitative proteomics Carbapenem Pseudomonas aeruginosa Meropenem Antimicrobial resistance Lc-ms/ms 
ProteomicsSurface-shaving of Staphylococcus aureus strains using Lipid-based Protein Immobilization (LPI) and quantitative proteomic analysis reveal differences in protein expression levels of the surfaceome
Staphylococcus aureus is a pathogen which can cause a wide range of infections. To find new targets for diagnostics and treatment as well as understanding host-pathogen interactions, many studies have focused on the bacterial surface proteins. In the study presented here, bacterial cell surface-shav...
ORGANISM(S): Staphylococcus aureus 
2024-10-17 | PXD025436 | Pride
Proteomics Relative quantification Mass spectrometry Virulence factors Staphylococcus aureus Surfaceome Tandem mass tags 
ProteomicsInsights of the metabolic adaptation to low concentrations of ertapenem of a carbapenem resistant Klebsiella pneumoniae strain
Klebsiella pneumoniae carrying antibiotic resistance against carbapenems are of great concern, due to the limited number of treatment options for infections caused by multiresistant bacteria. Novel antibiotics and treatment options are thus needed, and this need is exacerbated by the rapid and globa...
ORGANISM(S): Klebsiella pneumoniae 
2025-10-06 | PXD061842 | Pride
Quantitative proteomics Klebsiella pneumoniae Mass spectrometry Antibiotic resistance 
ProteomicsIdentification of antibiotic resistance proteins via MiCId's augmented workflow. A mass spectrometry-based proteomics approach
Fast and accurate identification of pathogenic bacteria along with the identification of antibiotic resistance proteins is of paramount importance for the treatment of patients and public health. While mass spectrometry has become an important technique for these purposes there is a lack of mass spe...
ORGANISM(S): Pseudomonas aeruginosa Klebsiella pneumoniae Escherichia coli 
2022-06-09 | PXD026634 | Pride
Identification of antibiotic resistance proteins Bacteria identification Mass spectrometry 
ProteomicsDiscovery of species-unique peptide biomarkers of bacterial pathogens by tandem mass spectrometry-based proteotyping
Respiratory-tract infections are a predominant cause for clinical treatment, although, clinical assessments and standard clinical laboratory protocols are time-consuming and often inadequate for reliable diagnoses. Novel methods, preferably applied directly to clinical samples, excluding cultivation...
ORGANISM(S): Haemophilus influenzae Moraxella catarrhalis Staphylococcus aureus Streptococcus pneumoniae (strain ATCC BAA-255 / R6) 
2020-01-17 | PXD014522 | Pride
Streptococcus pneumoniae Moraxella catarrhalis Staphylococcus aureus Bacteria Haemophilus influenzae Proteotyping 
ProteomicsMass Spectrometry Proteotyping-Based Detection and Identification of Staphylococcus aureus, Escherichia coli and Candida albicans in Blood
Bloodstream infections (BSIs), the presence of microorganisms in blood, are potentially serious conditions that can quickly develop into sepsis and life-threatening situations. When assessing proper treatment, rapid diagnosis is the key; besides clinical judgement performed by attending physicians, ...
ORGANISM(S): Candida albicans (Yeast) Escherichia coli Staphylococcus aureus 
2021-07-20 | PXD023033 | Pride
Bloodstream infections Proteotyping Pathogen identification Lc-ms/ms 
UnknownA Scaled Proteomic Discovery Study for Prostate Cancer Diagnostic Markers Using ProteographTM and Trapped Ion Mobility Mass Spectrometry.
Not available
S-EPMC11311733 | biostudies-literature
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