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ProteomicsDeciphering the involvement of the Hippo pathway co - regulators, YAP/TAZ in invadopodia formation and matrix degradation
Invadopodia are adhesive, actin - rich pro trusions , formed by metastatic cancer cells , that degrade the extracellular matrix and facilitate invasion . They support the metastatic cascade by a spatially and temporally coordinated process where by invading cells bind to the matrix , degrade it by s...
ORGANISM(S): Homo sapiens (Human) 
2023-03-20 | PXD034562 | Pride
Prote omic profiling Tks5 Extracellular matrix Yap Hippo pathway I nvadopodia Actin Taz Gelatin degradation Cancer metastasis Mmp14 (mt1 - mmp) Rna sequencing 
ProteomicsAn optimized glycopeptide enrichment method – it’s all about the sauce
Protein glycosylation is a family of post translational modifications (PTMs) that play a crucial role in cellular and tissue biology, and whose role in disease is unraveled with every new finding. Enrichment and analysis of such a diverse family of modification is very challenging, due to the number...
ORGANISM(S): Homo sapiens (Human) 
2022-06-29 | PXD031177 | Pride
Glycation Brain Glycopeptide Ptm Boronic acid Plasma 
ProteomicsOptimization of skeletal protein preparation for LC-MS/MS sequencing yields additional coral skeletal proteins in Stylophora pistillata
Stony corals generate their calcium carbonate exoskeleton in a highly controlled biomineralization process mediated by a variety of macromolecules including proteins. Fully identifying and classifying these proteins is crucial to understanding their role in exoskeleton formation, yet no optimal meth...
ORGANISM(S): Anthozoa Stylophora pistillata 
2020-06-16 | PXD017891 | Pride
Highly acidic proteins Cnidaria Centrifugal filtration Scleractinia Acetone precipitation 
ProteomicsAnti-SARS-CoV-2 antibodies elicited by COVID-19mRNA vaccine exhibits a unique glycosylation pattern
Messenger RNA-based vaccines against COVID-19 induce a robust anti-SARS-CoV-2 antibody response with potent viral neutralization activity. Antibody effector functions is determined by its constant region subclasses as well as by its glycosylation patterns, but their role in vaccine efficacy is not w...
ORGANISM(S): Homo sapiens (Human) 
2021-11-29 | PXD029321 | Pride
Sars-cov-2 Fc-glycosylation Antibody effector function Igg Antibodies Covid-19 Mrna vaccine Fcγ receptors 
ProteomicsTWIST1 methylation by SETD6 selectively antagonizes LINC-PINT expression in Glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor among adults, which is characterized by high invasion, migration and proliferation abilities. One important process that contributes to the invasiveness of GBM is the epithelial to mesenchymal transition (EMT). EMT...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD029361 | Pride
Glioblastoma Methylation Setd6 Methyltransferase 
UnknownTobacco smoking, NBS1 polymorphisms, and survival in lung and upper aerodigestive tract cancers with semi-Bayes adjustment for hazard ratio variation.
Not available
S-EPMC3889468 | biostudies-literature
UnknownAssociations between NBS1 polymorphisms, haplotypes and smoking-related cancers.
Not available
S-EPMC2893801 | biostudies-literature
UnknownThe revised Approved Instructional Resources score: An improved quality evaluation tool for online educational resources.
Not available
S-EPMC8194147 | biostudies-literature
UnknownObservation of quantum entanglement with top quarks at the ATLAS detector.
Not available
S-EPMC11410654 | biostudies-literature
TranscriptomicsAdaptaquin is an inhibitor of oxygen-sensing prolyl-hydroxylase domain enzymes that abrogates ATF4-dependent death and improves outcomes from brain hemorrhage
Disability or death secondary to intracerebral hemorrhage (ICH) is attributed to blood lysis, liberation of iron and generation of oxidative stress. Iron chelators bind free iron and prevent neuronal death induced by oxidative stress and disability due to ICH, but the mechanisms remain unclear. Here...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-75048 | biostudies-arrayexpress
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