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ProteomicsMitoStores: Chaperone-controlled protein granules store mitochondrial precursors in the cytosol - Data Set 2: Hsp104 AP-MS
Hundreds of mitochondrial precursor proteins are synthesized in the cytosol and imported into mitochondria in a post-translational reaction. The early stages in mitochondrial protein targeting are poorly understood. Here we show that in baker’s yeast, the cytosol has the capacity to transiently stor...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-15 | PXD035762 | Pride
Mitostores Mitochondrial import Hsp104 
ProteomicsMitoStores: Chaperone-controlled protein granules store mitochondrial precursors in the cytosol - Data Set 1: Global Proteome TMT
Hundreds of mitochondrial precursor proteins are synthesized in the cytosol and imported into mitochondria in a post-translational reaction. The early stages in mitochondrial protein targeting are poorly understood. Here we show that in baker’s yeast, the cytosol has the capacity to transiently stor...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-01-17 | PXD035760 | Pride
Mitochondrial import Ubiquitin proteasome system Rpn4 Mitostore 
ProteomicsThe ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria - Data Set 2
Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the ER-SURF pathway employ the surface of the endoplasmic reticulum (ER) as an important sorting platform. How they reach the...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-05 | PXD044368 | Pride
Contact sites. endoplasmic reticulum. ermes. er-surf. protein import. protein targeting. mitochondria 
ProteomicsDistinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress - Data Set5: TMT dataset of aggregates in mitochondria
Mitochondria consist of hundreds of proteins, most of which are long-lived and inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions is poorly understood. Here we show that mitochondria form spatially defin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-26 | PXD048691 | Pride
Mitochondria aggregates 
ProteomicsCognitive Decline in Older Adults with Type 2 Diabetes: Unraveling Site-Specific Glycoproteomic Alterations
Type 2 diabetes (T2D) is consistently associated with an elevated risk of cognitive decline and dementia. The underlying molecular mechanisms relating T2D to cognitive decline remain unclear, impeding the ability to detect the earliest stages of cognitive decline in older adults with T2D, consequent...
ORGANISM(S): Homo sapiens (Human) 
2025-02-16 | PXD050780 | Pride
Glycosylation Glycation Serum Glycoproteomics Plasma Cognition 
ProteomicsThe long non-coding RNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation
Numerous long non-coding RNAs (lncRNAs) were shown to have functional impact on cellular processes, such as human epidermal homeostasis, but for only a few the mode of action has been elucidated. Here, we report that lncRNA LINC00941 controls keratinocyte differentiation on a global level through as...
ORGANISM(S): Homo sapiens (Human) 
2024-04-08 | PXD043838 | Pride
Long non-coding rna Lc-msms Bivalency Differentiation Epidermis Nurd complex Linc00941 
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