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ProteomicsQuantitative Proteomics of Acutely Isolated Mouse Microglia Identifies Novel Immune Alzheimer's Disease-related Proteins
Microglia are innate immune cells of the brain that perform phagocytic and inflammatory functions in disease conditions. Transcriptomic studies of acutely-isolated microglia have provided novel insights into their molecular and functional diversity in homeostatic and neurodegenerative disease states...
ORGANISM(S): Mus musculus (Mouse) 
2018-09-18 | PXD009137 | Pride
Cd11b-positive Brain resident microglia 
TranscriptomicsDefining the microglia transcriptome during disease progression in ALS transgenic mice
Purpose: We purified spinal cord microglia utilizing percoll gradients and magnetic beads, followed by transcriptome profiling (RNA-seq) to define microglia expression profiles against other neural, immune cell-types. We next observed how the microglial transcriptomes change during activation in the...
ORGANISM(S): Mus musculus 
2013-07-15 | E-GEOD-43366 | biostudies-arrayexpress
ProteomicsComparison of microglial proteomes of MACS and FACS-based purified CD11b+ microglia
Background Proteomic characterization of microglia has been limited by low yield and contamination by non-microglial proteins by magnetic-activated cell sorting (MACS) enrichment strategies. To determine whether a fluorescent-activated cell sorting (FACS)-based strategy overcomes these limitations,...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-11 | PXD015652 | Pride
Mouse acutely purified brain-associated microglia Tmt Macs Facs 
TranscriptomicsA Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes
A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function Understanding the cell-cell interactions that control CNS development and function has long been limited by the lack of methods to cleanly separate astrocytes, neu...
ORGANISM(S): Mus musculus 
2007-12-30 | E-GEOD-9566 | biostudies-arrayexpress
UnknownQuantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins.
Not available
S-EPMC6025801 | biostudies-literature
TranscriptomicsAn RNA-Seq transcriptome and splicing database of neurons, glia, and vascular cells of the cerebral cortex
Purpose: To better understand the function of the various cell types of the brain, we prospectively purified neurons, astrocytes, oligodendrocyte precursor cells, newly formed oligodendrocytes, myelinating oligodendrocytes, microglia, endothelial cells, and pericytes from mouse cerebral cortex. We g...
ORGANISM(S): Mus musculus 
2014-08-15 | E-GEOD-52564 | biostudies-arrayexpress
GenomicsInflammatory signaling differentially changes chromatin accessibility and gene expression of the PD-associated kinase LRRK2 between human and mice [multiome mouse]
Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD-associated kinase LRRK2 between human and mice [multiome mouse]
PRJNA1336233 | ENA
GenomicsInflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice [ChIP-Seq]
Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice [ChIP-Seq]
PRJNA1335222 | ENA
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