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TranscriptomicsAscites enriches for ovarian cancer stem-like cells that express membrane GRP78
Ovarian cancer patients are generally diagnosed at stage III/IV, when ascites is common. The volume of ascites positively correlates with the extent of metastasis and negatively with prognosis. Membrane GRP78, a stress-inducible endoplasmic reticulum chaperone which also appears on the plasma membra...
ORGANISM(S): Mus musculus 
2015-03-09 | E-GEOD-61285 | biostudies-arrayexpress
ProteomicsIsolation of EVs from Minimal Ascites Fluid Volume
Using Mag-Net beads to capture EVs from murine and human ascites fluid. Determine minimal volume of starting material needed for parallel proteomics and SERS analysis.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-09-07 | PXD068766 | Pride
Ovarian cancer Dia Extracellular vesicles Ascites Mag-net 
TranscriptomicsInvestigation of the molecular mechanisms underlying of herb pair Daji and Gancao with different combination designs acting on hepatocellular carcinoma ascites mice
The differentially expressed genes among the blank control, ascites mouse model, Daji (DJ)/ Gancao (GC)-synergistic treatment and DJ/GC-antagonistic treatment groups were identified to investigate the molecular mechanisms underlying the herb pair DJ and GC acting on ascites mice. In the study, 50 ma...
ORGANISM(S): Mus musculus 
2016-01-20 | E-GEOD-76818 | biostudies-arrayexpress
TranscriptomicsHuman fetal chylothorax: pleural fluid vs. ascites fluid
Transcriptional profile comparison of the pleural and ascites fluids in hydropic fetuses affected with chylothorax. Two-condition experiment, pleural fluid vs. ascites fluid. Comparison of the transcriptional profile between sample collected before and after OK-432 treatment and between fetuses with...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-33872 | biostudies-arrayexpress
ProteomicsCD28 co-stimulatory domain enhances efficacy of CER T cell therapy compared to 4-1BB in an ovarian cancer mouse model
Ovarian cancer remains a significant cause of cancer-related mortality, with epithelial ovarian cancer (EOC) being the most common subtype. Despite advances in treatment, the 5-year survival rate for late-stage EOC remains low due to factors such as tumor heterogeneity and an immunosuppressive tumor...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-27 | PXD066774 | Pride
Astral ms Lc-ms Mouse ascites 
TranscriptomicsRNA-seq analysis of ID8 ovarian cancer cells after harvest from malignant ascites
Sequencing of mRNA from ID8 tumor cells and ID8 tumor cells harvested from ascites of mice 11 weeks after intra peritoneal inoculation show acquisition of cancer stem cell-like features in ascitic tumor cells.
ORGANISM(S): Mus musculus 
2020-01-06 | E-MTAB-8140 | biostudies-arrayexpress
TranscriptomicsGenome-wide mRNA expression analysis of the impact of electron radiation on Daltons lymphoma ascites cells in vivo
The gene expression changes induced upon electron radiation in cancer cells is largely unexplored. We investigated the effect of electron radiation generated from 8 MeV Microtron in Daltons lymphoma ascites (DLA) cells bearing mice model. Mice implanted with DLA cells in their peritoneal cavity were...
ORGANISM(S): Mus musculus 
2013-03-05 | E-GEOD-44908 | biostudies-arrayexpress
TranscriptomicsA platform of patient-derived tumor xenografts (EOC-xenografts) to recapitulate the clinicopathology and genetic alterations of ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. On the basis of its histopathology and molecular-genomic changes ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC-xen...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-56920 | biostudies-arrayexpress
Transcriptomics17β-estradiol accelerates ovarian tumour progression in vivo though the upregulation of GREB1
Exogenous 17β-estradiol (E2) accelerates the progression of ovarian cancer in the transgenic tgCAG-LS-TAg mouse model of the disease. We hypothesized that E2 has direct effects on ovarian cancer cells and this study was designed to determine the molecular mechanisms by which E2 accelerates ovarian t...
ORGANISM(S): Mus musculus 
2014-01-20 | E-GEOD-45271 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of ovarian tumors from mice with knockout of DICER and PTEN
The cell of origin of serious ovarian cancer is unknown. To create a mouse model for this lethal cancer and identify early cancer biomarkers, we conditionally deleted both Dicer (essential for microRNA biosynthesis) and Pten (a negative regulator of the PI3K pathway) in the female reproductive tract...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-28720 | biostudies-arrayexpress
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