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MetabolomicsActivation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure

Heightened sterile inflammation and mitochondrial metabolic dysfunction drives the pathophysiology of heart failure in ischemic cardiomyopathy. Yet, the transcriptional regulators within cardiomyocytes driving crosstalk between inflammation and energy metabolism remain ill-defined. Here we identi...

2026-01-28 | MTBLS13783 | MetaboLights
ProteomicsThe role of Rpl3l in translation in cardiomyocytes
Ribosome immunoprecipitates of cardiomyocytes isolated from Rpl3l-/- and Rpl3l+/+ mouse hearts were analysed using mass spectrometry.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-08 | PXD026985 | Pride
Rpl3 Cardiomyocytes Rpl3l 
ProteomicsBioinformatic analysis of membrane and associated proteins in murine cardiomyocytes and human myocardium
In the current study we examined several proteomic- and RNA-Seq-based datasets of cardiac-enriched, cell-surface and membrane-associated proteins in human fetal and mouse neonatal ventricular cardiomyocytes. By integrating available microarray and tissue expression profiles along with MGI phenotypic...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2020-11-17 | PXD017732 | Pride
Bioinformatics Therapeutics Cardiomyocytes Membrane proteins Heart disease 
TranscriptomicsDirect reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails
The direct conversion, or trans-differentiation, of non-cardiac cells into cardiomyocytes by forced expression of transcription factors and microRNAs provide promising ways of cardiac regeneration. However, genetic manipulations are still not desirable in real clinical applications. we report the ge...
ORGANISM(S): Mus musculus 
2015-08-23 | E-GEOD-69924 | biostudies-arrayexpress
ProteomicsAdult mouse cardiomyocytes in early stage of pressure overload
Adult cardiomyocytes from mouse hearts under 3 days of pressure-overload induced by transverse aortic constriction
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD021671 | Pride
Cardiomyocytes Cardiac hypertrophy Pressuer ovelroad 
TranscriptomicsTranscriptome modulation of ventricles, cardiomyocytes and cardiac fibroblasts during postnatal mouse development
During development the fetal heart undergoes a rapid and dramatic transition to adult function through transcriptional and post-transcriptional mechanisms, including alternative splicing (AS). We performed deep RNA-sequencing for high-resolution analysis of transcriptome changes during postnatal mou...
ORGANISM(S): Mus musculus 
2014-04-16 | E-GEOD-49906 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array and functional characterization of developing cardiomyocytes from recombinant murine embryonic stem cells
Here, we characterize the transcriptome of the mouse embryonic stem cell line CM7-1 during differentiation into beating cardiomyocytes and compared the gene expression profiles with those from primary adult murine cardiomyocytes and left ventricular myocardium.
ORGANISM(S): Mus musculus 
2009-03-21 | E-MEXP-1405 | biostudies-arrayexpress
ProteomicsThe N-cadherin interactome in primary cardiomyocytes as defined by quantitative proximity proteomics
Low levels of Cdh2-BioID2 were expressed in mouse primary neonatal cardiomyocytes using an adenoviral expression system. Infected cells were treated with biotin for 24 hours before lysis. Biotinylated proteins were precipitated from lysates using streptavidin beads. Protein samples were in-gel tryps...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-01-24 | MSV000083362 | MassIVE
OtherThe N-cadherin interactome in primary cardiomyocytes
Low levels of Cdh2-BioID2 were expressed in mouse primary neonatal cardiomyocytes using an adenoviral expression system. Infected cells were treated with biotin for 24 hours before lysis. Biotinylated proteins were precipitated from lysates using streptavidin beads. Protein samples were in-gel tryps...
ORGANISM(S): Mus Musculus 
2019-01-23 | MSV000083356 | MassIVE
TranscriptomicsSf3b1-dependent splice factor expression and alternative splicing in NMC
Neonatal mouse cardiomyocytes (NMC) were cultured in hypoxia (3% O2) with and without a lentiviral shRNA-mediated knockdown of Sf3b1. Total RNA was extracted from NMC using RNeasy kit, cDNA was synthesized using GeneChip WT cDNA Synthesis and Amplification kit (Affymetrix 900673) and hybridised to A...
ORGANISM(S): Mus musculus 
2018-01-03 | E-MTAB-3203 | biostudies-arrayexpress
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