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Proteomicshigh fat diet feed mice liver sample proteomics
determine the effect of the high-fat diet on the proteomics profile of liver tissue.Mice were fed with HFD for 16 weeks to establish a NAFLD mouse model. Mice fed with normal chow diet were taken as controls. Five replicate liver samples were collected from each group for proteomics analysis.
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD030727 | Pride
Mouse hfd liver proteomics 
ProteomicsPlatycodi Radix Extract Prevents Hepatic Steatosis by Enhancing Bile Acid Synthesis in a High-Fat Diet-Induced Fatty Liver Mouse Model
This project investigated the molecular mechanism by which *Platycodi Radix* extract (PRE; the ethanol extract of the root of *Platycodon grandiflorum*) prevents non-alcoholic fatty liver disease (NAFLD) in a high-fat diet (HFD)-induced fatty liver mouse model, using a liver-tissue shotgun proteomic...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-04 | PXD080181 | Pride
Platycodon radix Proteomics Obesity Nafld 
ProteomicsProteomic detection of mouse liver
This study aimed to investigate the mechanism of SYT on lipid metabolism and insulin sensitivity in high-fat diet (HFD)-induced obese mice by means of combining lipidomics and proteomics. The obese mice models were developed via HFD feeding for 20 consecutive weeks. Mice in the treatment group were ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD028317 | Pride
Mouse Liver 
ProteomicsProteomics of liver from mice fed high fat diet (HFD) or regular chow diet
Proteomics of liver tissue from mice fed a high fat diet (HFD) or regular chow diet. Data accompany our paper entitled “Dynamic Regulation of N6,2′-O-dimethyladenosine (m6Am) in Obesity” scheduled for publication in Nature Communications, 2021
ORGANISM(S): Mus musculus (Mouse) 
2021-10-27 | PXD029280 | Pride
Mouse Liver High fat diet 
UnknownQuantitative proteomics of HFD-induced fatty liver uncovers novel transcription factors of lipid metabolism.
Not available
S-EPMC9134917 | biostudies-literature
ProteomicsLifestyle Matters (LiMa) Mice Liver Histone Proteomics
The LiMa project consist of a C57BL/6JOlaHSD mice model with three experimental groups: control (CNT), high fat diet (HFD) fed, and HFD fed subjected to a lifestyle intervention (INT). The project objectives is to study how the HFD and intervention shape liver metabolism and how these changes intera...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-27 | PXD084769 | Pride
High fat diet Hfd Mice Histone Liver Intervention 
ProteomicsProteomics reveals PFOS-induced alteration of lipid utilization and xenobiotic metabolism in a model of PFOS-augmented diet-induced fatty liver
Perfluorooctanesulfonic acid (PFOS) is a persistent, bio-accumulative pollutant that has been used for the last 60+ years in numerous industrial and commercial applications. In mice, PFOS administration is known to induce hepatomegaly and hepatic steatosis. The aim of the present study was to evalua...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-30 | PXD016161 | Pride
Perfluorinated compounds Pfos Proteomics Liver High fat diet Weight loss Nafld 
ProteomicsMouse liver expression additional replicates
This study sought to interrogate the effects of lipids and lipid metabolites on the hepatic proteome. Protein expression in high-fat diet (HFD) mouse livers vs. livers of normal chow fed (NC) mice were investigated using multiplexed quantitative LC-MS/MS (TMT labeling). This experiment contains addi...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-08 | PXD013815 | Pride
Mouse Liver Expression High-fat diet Lc-ms/ms 
ProteomicsSignatures of Proteomics and Glycoproteomics Reveal Liraglutide Ameliorates NAFLD by Regulating Specific Metabolic Homeostasis in Mice
Liraglutide, a GLP-1 receptor agonist approved for diabetes and obesity, shows promise in treating NAFLD, the most prevalent chronic liver disease globally. Despite its therapeutic potential, the systematic molecular regulations underlying Liraglutide effects on NAFLD remain underexplored, indicatin...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-15 | PXD055468 | Pride
Liraglutide Proteomics Fatty acid N-glycosylation site Nonalcoholic fatty liver disease 
ProteomicsMouse and rat liver and liver cell line LC-MS/MS
This study sought to interrogate the effects of lipids and lipid metabolites on the hepatic proteome. Protein expression and tyrosine phosphorylation in high-fat diet (HFD) mouse livers vs. livers of normal chow fed (NC) mice were investigated using multiplexed quantitative LC-MS/MS (TMT labeling). ...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2019-07-08 | PXD011458 | Pride
Mouse Rat Free fatty acids Liver Phosphotyrosine Lc-ms/ms Diabetes 
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