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The Neurotrophic Compound J147 Reverses Cognitive Impairment In Aged Alzheimer's Disease We used GeneChipM-BM-. Mouse Genome 430 2.0 Arrays to probe global gene expression changes when adding J147 compound to HT22 cells and compared to untreated cells. The hippocampal cell line HT22 were treated wit...
ORGANISM(S): Mus musculus 
Chromatin Immunoprecipitation analysis of mouse hippocampal neuron HT22 cells
The aim of this project is to use an integrated approach involving SILAC labeling, HPLC fractionation, Phospho(STY) antibody affinity enrichment, LC-MS/MS to quantify the dynamic changes of the whole phosphorylome in the control and experimental samples.
ORGANISM(S): Mus musculus (Mouse) 
2018-10-27 | PXD004687 | Pride
The Neurotrophic Compound J147 Reverses Cognitive Impairment In Aged Alzheimer's Disease We used GeneChip® Mouse Genome 430 2.0 Arrays to probe global gene expression changes when adding J147 compound to HT22 cells and compared to untreated cells. The hippocampal cell line HT22 were treated with the...
ORGANISM(S): Mus musculus 
2013-03-28 | GSE45534 | GEO
Whole transcriptome sequencing of HT22 immortalized mouse hippocampal cells treated with AA147 or veh for 16 h
Transcriptomic evaluation of Mef2c manipulation in the mouse brain and HT22 cells
Genome-wide analysis of gene expression in wild-type and KMT2D-deficient HT22 cells
Astrocytes can support neuronal survival through a range of secreted signals that protect against neurotoxicity, oxidative stress, and apoptotic cascades. To identify proteins contributing to protective intracellular neuronal signalling originating from astrocytes, endogenous PI3K was immunoprecipi...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022200 | Pride
We used H4K5bu and H4K5ac antibodies to specifically enrich mouse hippocampal neuronal cells (HT22) before and after BHBA administration. We found that the acetylation and butylation of histone H4K5 play a key role in the neuroprotection of BHBA.
ORGANISM(S): Mus musculus 
2021-04-09 | GSE171743 | GEO
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