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MetabolomicsTen Mouse Organs Proteome and Metabolome Atlas from Adult to Aging

The complexity of the aging process, encompassing numerous organs and systems, poses a significant challenge in identifying and targeting key factors that drive age-related decline. The multi-organ synchronous molecular intricacies underlying natural aging remain elusive. Here we presented a data...

2025-08-29 | MTBLS10642 | MetaboLights
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
ProteomicsData-Independent Acquisitions Uncover Kidney Proteome Remodeling during Ischemic Reperfusion Kidney Injury using a Fast-scanning ZenoTOF 7600
Acute kidney injury (AKI) manifests as a major health concern particularly for the elderly and understanding related proteome changes is critical for prevention and development of novel therapeutics to recover kidney function, and to mitigate the susceptibility for recurrent AKI, or development of c...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-11-23 | MSV000090777 | MassIVE
ProteomicsSystemic toxicity of snake venom metalloproteinases: proteomics analyses of kidney injury and blood plasma disturbances in a mouse model
Metalloproteinases are abundant in viperid venoms and are implicated in several envenomation effects. Bothrops jararaca venom is reported to induce kidney injury and coagulopathy. HF3 is an extremely hemorrhagic metalloproteinase from B. jararaca venom and participates in the local pathogenesis of e...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-01-20 | MSV000091101 | MassIVE
MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine kidney and plasma UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS680 | MetaboLights
ProteomicsEffects of the differential K+ diets on mouse kidney cortex tissue
In this project, we investigated the global proteome alteration in mouse kidney cortex tissues after differential K+ diet treatments. TMTpro labeling strategy was used to obtain protein quantification information from LC-MS based proteomic analysis.
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD035354 | Pride
Potassium Mouse Kidney 
ProteomicsProteomic analysis of cisplatin exposure on the kidney cortex proteome and the effect of preconditioning
Acute kidney injury and nephrotoxicity are important clinical side effects of cisplatin. Thus, the mechanisms of this disease, and potential treatment options are important to understand in their entity. Here, we analyzed the proteome of cisplatin induced acute kidney injury in a mouse model. Functi...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-30 | PXD005525 | Pride
Caloric restriction Cisplatin Kidney 
ProteomicsLiraglutide effect on STZ Mouse Kidney with diabetic nephropathy
The effect of liraglutide on the kidney proteome in the STZ mouse model compared to healthy and STZ diabetic control groups.
ORGANISM(S): Mus musculus (Mouse) 
2019-01-18 | PXD003007 | Pride
Liraglutide Kidney Proteome Stz Shotgun Diabetes nephropathy Label-free 
ProteomicsMouse liver and kidney proteome with antibiotics treatment
Dysbiosis (alteration of intestinal flora) is associated with various host physiologies, including diseases. The purpose of this study was to clarify the effect of dysbiosis on protein expression levels in mouse liver and kidney by quantitative proteomic analysis, focusing in particular on drug-meta...
ORGANISM(S): Mus Musculus (mouse) 
2018-01-01 | PXD008237 | JPOST Repository
ProteomicsMouse kidney cisplatin TAILS - The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury
Profiling of proteolytic events mouse kidneys during cisplatin-induced kidney damage. Kidneys from vehicle-treated mice are compared to cisplatin-treated mice and cisplatin treatment in animals preconditioned by hypoxia or calory restriction regimes.
ORGANISM(S): Mus musculus (Mouse) 
2018-10-29 | PXD007186 | Pride
Mouse  kidney 
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