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ProteomicsDevelopmental mRNA clearance by PIWI-bound endo-siRNAs in Paramecium
The clearance of untranslated mRNAs by Argonaute proteins is essential for embryonic development in metazoans. However, it is currently unknown whether a similar process exists in unicellular eukaryotes. The ciliate Paramecium tetraurelia harbors a vast array of Argonaute proteins of the Piwi-clade ...
ORGANISM(S): Paramecium tetraurelia 
2023-05-10 | PXD038984 | Pride
Paramecium tetraurelia Piwi Mrna clearance Untranslated mrna Total protein < 25kda Sirnas 
TranscriptomicsGlobal characterization of the oocyte-to-embryo transition in C. elegans uncovers a novel mRNA turnover mechanism
The oocyte-to-embryo transition (OET) is thought to be mainly driven by post-transcriptional gene regulation. However, expression of both RNAs and proteins during the OET has not been comprehensively assayed. Furthermore, specific molecular mechanisms that regulate gene expression during OET are lar...
ORGANISM(S): Caenorhabditis elegans 
2014-07-02 | E-GEOD-58141 | biostudies-arrayexpress
GenomicsYthdf2-mediated m6A mRNA clearance modulates neural development in mice
Ythdf2-mediated m6A mRNA clearance modulates neural development in mice
PRJNA414058 | ENA
TranscriptomicsEndosome-associated lc3b mRNA is translated in axons and the protein contributes to endosomal clearance
The primary objective of this project was to identify transcripts in close proximity to endosomes using the APEX-seq approach. To achieve this, we employed SH-SY5Y cells expressing APEX2-NES, APEX2-RAB5A, or 2xFYVE-APEX2 constructs. Biotinylation of RNAs was validated by dot blot, and biotinylated R...
ORGANISM(S): Mus musculus 
2026-09-01 | E-MTAB-15783 | biostudies-arrayexpress
ProteomicsLSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance
Fully grown oocytes remain transcriptionally quiescent, yet many maternal mRNAs are synthesized and retained in growing oocytes. We now know that maternal mRNAs are stored in a structure called the mitochondria associated ribonucleoprotein domain (MARDO). But the components and functions of MARDO re...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-17 | PXD042761 | Pride
Lsm14b  oocyte meiotic maturation  mrna storage 
GenomicsLSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance
LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance
PRJNA967243 | ENA
TranscriptomicsTranscription profiling of Zebrafish embryos investigating the effect of miR-430 microRNA on deadenylation and clearance of maternal mRNAs
MicroRNAs comprise 1-3% of all vertebrate genes, but their in vivo functions and mechanisms of action remain largely unknown. Zebrafish miR-430 is expressed at the onset of zygotic transcription and regulates morphogenesis during early development. Using a microarray approach and in vivo target vali...
ORGANISM(S): Danio rerio 
2007-10-05 | E-GEOD-4201 | biostudies-arrayexpress
TranscriptomicsGene expression analysis during acute hepatitis C virus infection associates dendritic cell activation with viral clearance
Background and Aims: Viral clearance during acute hepatitis C virus (HCV) infection is associated with the induction of potent antiviral T-cell responses. Since dendritic cells (DC) are essential in the activation of primary T-cell responses our goal was to analyze gene expression in DC from patient...
ORGANISM(S): Homo sapiens 
2016-07-29 | E-GEOD-65123 | biostudies-arrayexpress
GenomicsCharacterization of Zygotic Genome Activation-dependent Maternal mRNA Clearance in Mammals
Characterization of Zygotic Genome Activation-dependent Maternal mRNA Clearance in Mammals
PRJNA527011 | ENA
ProteomicsEDC-3 and EDC-4 Regulate Embryonic mRNA Clearance and Biomolecular Condensate Specialization
Animal development is dictated by the selective and timely decay of mRNAs in developmental transitions. The implication of mRNA decapping scaffold proteins in these processes was unknown. This study delineates the roles and interactions of the DCAP-2 decapping scaffolds EDC-3 and EDC-4 in the embryo...
ORGANISM(S): Caenorhabditis Elegans (ncbitaxon:6239) 
2024-02-02 | MSV000093990 | MassIVE
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