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ProteomicsmTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.
The mTOR complex 2 (mTORC2) has been implicated as a key regulator of glioblastoma cell migration. However, the roles of mTORC2 in the migrational control process have not been entirely elucidated. Here we elaborate that mTORC2 is crucial for GBM cell motility. Inhibition of mTORC2 resulted in impai...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD035256 | Pride
Glioblastoma Ap-ms Mtorc2 interactome Cell migration Gelsolin 
UnknownmTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.
Not available
S-EPMC10148843 | biostudies-literature
ProteomicsStable Cas9 Expression on Cell Growth Regulation Through mTORC2 Activation Facilitation
CRISPR, widely used for gene editing, relies on bacterial endonucleases like Cas9 to study gene functions and develop therapies. However, its potential effects on mammalian cellular responses and behavior remain unclear. Here, we systematically profiled effects of stable Cas9 expression on growth of...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD064062 | Pride
Du145 Mda-mb-231 
UnknownStable Cas9 expression regulates cell growth by facilitating mTORC2 activation.
Not available
S-EPMC12477591 | biostudies-literature
ProteomicsHSP27 Functional Switch Drives Castration-Resistant Prostate Cancer via mTOR Pathway Activation, Highlighting Promising Combination Therapies to Restore Treatment Sensitivity
Heat shock protein 27 (HSP27) is a multifunctional protein that plays pivotal roles in prostate cancer (PC) progression to a castration-resistant state, known as CRPC. In this study, we identified and analyzed HSP27-protein interaction maps across various prostatic cell models recapitulating differe...
ORGANISM(S): Homo sapiens (Human) 
2026-07-21 | PXD056858 | Pride
Ap-ms Lc-msms Castration resistant prostate cancer (crpc) Hsp27 Mtor pathway Interactome 
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