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TranscriptomicsmicroRNA expression and opioid signaling
To study the relationship between microRNAs and μ-opioid receptor (MOR) signaling, we examined microRNA expression after chronic morphine or fentanyl treatment in rat primary hippocampal neurons and in mouse hippocampus. Mouse cerebellum region was also tested as a negative control to eliminate mic...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-14268 | biostudies-arrayexpress
ProteomicsLigand-dependent spatiotemporal signaling profiles of the mu-opioid receptor are controlled by distinct protein-protein interaction networks
Ligand-dependent differences in the regulation and internalization of the mu-opioid receptor (MOR) have been linked to the degree of severity of the side effects that limit the use of opiates in the treatment of pain. For example, activation of the MOR by morphine and DAMGO ([D-Ala2,N-MePhe4,Gly-ol]...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD013328 | Pride
Proteomics Ras‐related c3 botulinum toxin substrate 1 (rac1) Extracellular signal regulated kinase (erk) Desmosome G protein-coupled receptor (gpcr) Cell compartmentalization Protein complex Opioid 
ProteomicsProfiling the diversity of agonist-selective effects on the proximal proteome environment of G protein-coupled receptors
G protein-coupled receptors (GPCRs) regulate many aspects of physiology and represent actionable targets for drug discovery. Activation of specific signaling pathways downstream of G-protein coupled receptors (GPCRs) or targeting the receptors at selected cellular locations has the potential to prov...
ORGANISM(S): Homo sapiens (Human) 
2024-03-30 | PXD031415 | Pride
Ap-ms Mu opioid receptor Dia Apex Gpcr Dda 
ProteomicsAntagonism of the Mu-Delta Opioid Receptor Heterodimer Enhances Opioid Anti-Nociception by Activating Src and CaMKII Signaling
The opioid receptors are important regulators of pain, reward, and addiction. Limited evidence suggests the mu and delta opioid receptors form a heterodimer (MDOR), which may act as a negative feedback brake on opioid-induced analgesia. However, evidence for the MDOR in vivo is indirect and limited,...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD022106 | Pride
Opiod mdor oxymorphone nociception 
GenomicsLysosomal Downregulation of the Mu Opioid Receptor is Opposed by the Retromer Complex
Lysosomal Downregulation of the Mu Opioid Receptor is Opposed by the Retromer Complex
PRJNA1193518 | ENA
ProteomicsProfiling the diversity of agonist-selective effects on the proximal proteome environment of G protein-coupled receptors
G-protein coupled receptors (GPCRs) regulate various aspects of cellular behavior and represent actionable targets for drug discovery. Activation of specific signaling pathways downstream of G-protein coupled receptors (GPCRs) or targeting the receptors at selected cellular locations has the potenti...
ORGANISM(S): Homo Sapiens 
2024-03-31 | PXD031393 | panorama
OtherLysosomal Downregulation of the Mu Opioid Receptor is Opposed by the Retromer Complex
The mu opioid receptor (MOR) is protected from opioid-induced trafficking to lysosomes and proteolytic downregulation by its ability to access the endosomal recycling pathway through its C-terminal recycling motif, LENL. MOR sorting towards the lysosome results in downregulation of opioid signaling ...
ORGANISM(S): Homo sapiens 
2026-02-17 | GSE283358 | GEO
GenomicsSpatial transcriptomics reveals distinct cell type dynamics following opioid dependence in female mice with the common human mu-opioid receptor variant, Oprm1 A118G
Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in female mice with the common human mu-opioid receptor variant, Oprm1 A118G
PRJNA1445882 | ENA
ProteomicsA mu opioid receptor superagonist that produces analgesia with minimal adverse effects
Developing safe and effective pain medications is an ongoing challenge for human health. Mu opioid receptor (MOR) agonists are essential pain medications, but their high intrinsic efficacy induces adverse side effects, including respiratory depression, constipation, tolerance, dependence, withdrawal...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD062863 | Pride
Mor Apex Opioids 
GenomicsCharacterization of mu opioid receptor cells in a new Oprm1-cre mouse
Characterization of mu opioid receptor cells in a new Oprm1-cre mouse
PRJNA904324 | ENA
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