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TranscriptomicsSpecific modulation of mucosal immune response, tolerance and proliferation in mice colonized with A. muciniphila
Epithelial cells of the mammalian intestine are covered with a mucus layer that prevents direct contact with intestinal microbes but also constitutes a substrate for mucus-degrading bacteria. To study the effect of mucus degradation on the host response, germ-free mice were colonized with Akkermansi...
ORGANISM(S): Mus musculus 
2011-09-20 | E-GEOD-18587 | biostudies-arrayexpress
ProteomicsMdpS and MdpS2 structurally and functionally diverge to regulate Streptococcus oralis mucin degradation
The human oral cavity harbors a diverse microbial community, with oral streptococci, particularly the Streptococcus mitis group, playing a pivotal role in biofilm formation and oral health. Among these, Streptococcus oralis is a key early colonizer that stabilizes oral biofilms. Here, we identify tw...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD062603 | Pride
Muc5b Streptococcus oralis Biofilm dynamics Mucin degrading proteases Oral microbiome Mucin degradation 
ProteomicsDesign of a mucin-selective protease for targeted degradation of cancer-associated mucins
Targeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Here, to expand the landscape of targetable substrates, we designed degraders that achieve substrate selectivity via recognition of a discrete peptide- and glycan- motif and achieve cell-typ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-21 | PXD042243 | Pride
Mucins Glycoprotease Targeted degradation Tails 
Genomics
Mucin degradation in gut microbiota
PRJNA821621 | ENA
UnknownEfficient mucin O-glycan degradation by specific mucin degrading intestinal bacteria: towards understanding enzyme-glycan interactions.
Not available
S-EPMC12834350 | biostudies-literature
MetabolomicsSynergistic metabolism of salivary MUC5B in oral commensal bacteria during early biofilm formation

Bacterial metabolism in oral biofilms is comprised of complex networks of nutritional chains and biochemical regulations. These processes involve both intraspecies and interspecies networks as well as interactions with components from host saliva, gingival crevicular fluid, and dietary intake. In...

2023-10-30 | MTBLS8370 | MetaboLights
TranscriptomicsIdentification of glycosyltransferases and glycosydases responsible for the synthesis/degradation of mucin O-glycans at the human ocular surface epithelium
The major focus of Dr. Argueso's research is to characterize the carbohydrate portion of the different mucins expressed by the ocular surface epithelia as well as the enzymes involved with their synthesis, and to determine whether the alteration of mucin glycosylation is associated with ocular surfa...
ORGANISM(S): Homo sapiens 
2011-03-02 | E-GEOD-27593 | biostudies-arrayexpress
UnknownDistinct in vitro utilization and degradation of porcine gastric mucin glycans by human intestinal bacteria.
Not available
S-EPMC12258148 | biostudies-literature
ProteomicsPeptide and MUC5B hydrolysis by the Mucin Degrading Protease (MdpL) from Limosilactobacillus fermentum
MUC5B is the predominant glycoprotein in saliva and is instrumental in the establishment and maintenance of multi-species eubiotic biofilms in the oral cavity. Investigations of the aciduric Lactobacillaceae family, and its role in biofilms emphasizes the diversity across different genera of the pro...
ORGANISM(S): Homo sapiens (Human) 
2023-03-22 | PXD039681 | Pride
Iob Mdpl Limosilactobacillus fermentum Muc5b Neuromedin Mog Lc-msms 
ProteomicsBinding of Akkermansia muciniphila to mucin is O-glycan specific
The intestinal anaerobic bacterium Akkermansia muciniphila is specialized in the degradation of mucins, which are heavily O-glycosylated proteins that constitute the major components of the mucus lining the intestine. Despite that adhesion to mucins is considered critical for the persistence of A. m...
ORGANISM(S): Homo sapiens (Human) 
2024-05-30 | PXD051738 | Pride
Akkermansia muciniphila Mucin O-glycan 
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