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TranscriptomicsTranscription profiling of rat spinal cord with experimental autoimmune encephalomyelitis at 3 disease points, acute, relapsing and recovering vs. controls
The intention of the study was to examine the spinal cord gene expression at three different EAE disease points and to compare them with three nonimmunised, healthy rats. We immunised female DA rats with recombinant MOG-protein and sacrificed them during the acute phase of EAE defined as the first E...
ORGANISM(S): Rattus norvegicus 
2007-05-15 | E-MEXP-1025 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of cerebrospinal fluid cells of multiple sclerosis patients
RNA was isolated from fresh cerebrospinal fluid samples of multiple sclerosis and control patients and analyzed by hybridization of HG U133 plus 2.0 arrays in order to investigate disease mechanisms of multiple sclerosis and to identify transcriptional biomarker
ORGANISM(S): Homo sapiens 
2014-06-01 | E-MTAB-2374 | biostudies-arrayexpress
ProteomicsIgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcus aureus
Best known for their roles in allergic diseases, the physiologic function of immunoglobulin E (IgE) and mast cells (the so-called allergy module of immunity) has been enigmatic. Recent evidence shows that allergic reactions can help to protect against the toxicity of venoms. As bacteria are a potent...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-10 | PXD019107 | Pride
Human allergies Mast cells Ige antibodies Host defense Bacterial infection 
ProteomicsIdentifying Kinase Substrates via a Heavy ATP Kinase Assay and Quantitative Mass Spectrometry
Mass spectrometry‐based in vitro kinase screens play an essential role in the discovery of kinase substrates, however, many suffer from biological and technical noise or necessitate genetically‐altered enzymecofactor systems. We describe a method that combines stable γ‐[18O2]‐ATP with classical in v...
ORGANISM(S): Homo sapiens (Human) 
2018-10-17 | PXD002133 | Pride
Human Kinase substrates  in vitro kinase assay  proteomics  mass spectrometry  heavy atp  non receptor tyrosine kinase abl1 
ProteomicsA common cell state in Triple Negative Breast Cancers can be targeted through inhibition of Spleen Tyrosine Kinase (SYK)
Breast tumors are highly heterogeneous and for many molecular subtypes no targeted therapies are available. These include breast cancers that display hallmarks of epithelial to mesenchymal transition (EMT), a process related to metastasis and enriched in triple negative breast cancers (TNBCs). To de...
ORGANISM(S): Homo sapiens (Human) 
2016-06-15 | PXD001680 | Pride
Syk inhibition Phosphotyrosine proteomics Human breast cancer 
GenomicsA Genome-Wide Association Study of Peripheral Arterial Disease

The Electronic Medical Record Phenotypes and Community-engaged Genomic Association Study aims to identify genetic variants mediating susceptibility to peripheral arterial disease (PAD). The study leverages a biorepository of blood samples of 1688 PAD cases and 1649 controls, and the electronic ...

phs000203.v1.p1 | EGA
ProteomicsCalreticulin mutated hematopoietic cells are vulnerable to ATR-CHK1 pathway inhibition
Disease frameshift mutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia (ET) and primary myelofibrosis (PMF). To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we aimed to search for small molecule drugs th...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD026803 | Pride
Mouse Mpn Calreticulin mutant Myeloproliferative neoplasms Atr-chk1 pathway 
ProteomicsAcute BAF perturbation causes immediate changes in chromatin accessibility
Loss-of-function mutations in genes coding for subunits of the large, multifarious BRG1/BRM associated factor (BAF) chromatin remodeling complexes are frequently causative for cancer or developmental diseases1-5. Cells lacking the most frequently mutated subunits like the ATPase SMARCA4 typically ex...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD018381 | Pride
Atac-seq Enhancer Dtag knock-in Chromatin remodeling Baf complex Chromatin accessibility Acute chemical degradation Synthetic lethality Mammalian swi/snf complex Kinetics 
ProteomicsIgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cells
In contrast to their clearly defined roles in allergic diseases, the physiologic functions of Immunoglobulin E antibodies (IgEs) and mast cells (MCs) remain enigmatic. Recent research supports the toxin hypothesis, showing that MCs and IgE-related type 2 immune responses can enhance host defense aga...
ORGANISM(S): Homo sapiens (Human) Apis mellifera (Honeybee) 
2021-11-25 | PXD023851 | Pride
Honeybee venom  host defense  ige  mast cells  toxin hypothesis 
ProteomicsNuclear Condensation of NUP98-Fusion Proteins drives leukemogenic gene expression NUP98-fusion protein drive oncogenic gene expression via nuclear/biomolecular condensation
NUP98-fusion proteins cause leukemia via unknown molecular mechanisms. All NUP98-fusion proteins share an intrinsically disordered region (IDR) featuring >35 repeats of Phenylalanine-Glycine (FG) in the NUP98 N-terminus. Conversely, C-terminal NUP98-fusion partners often have critical functions in g...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD022518 | Pride
Aml Ap-ms Fusion protein Nup98 Bicon-ms Condensate 
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