Sort   by:  
 Page size 
MetabolomicsMetabolic Profiling of Volatile Organic Compounds (VOCs) Emitted by the Pathogens Francisella tularensis and Bacillus anthracis in Liquid Culture
We conducted comprehensive (untargeted) metabolic profiling of volatile organic compounds (VOCs) emitted in culture by bacterial taxa Francisella tularensis (F. tularensis) subspecies novicida and Bacillus anthracis (B. anthracis) Sterne, surrogates for potential bacterial bioterrorism agents, as we...
2020-08-20 | MTBLS1737 | MetaboLights
ProteomicsOntology-guided clustering enables proteomic analysis of rare pediatric disorders
The study of rare pediatric disorders is fundamentally limited by small patient numbers, making it challenging to draw meaningful conclusions about their molecular basis. To address this, we developed a framework that integrates clinical ontologies with proteomic profiling, enabling the systematic a...
ORGANISM(S): Homo sapiens (Human) 
2025-06-10 | PXD058960 | Pride
Pediatrics / plasma / proteomics / snomed ct / urine 
ProteomicsA novel hybrid high speed mass spectrometer allows rapid translation from biomarker candidates to targeted clinical tests using 15N labeled proteins
Recent developments in affinity binder or mass spectrometry (MS)-based plasma proteomics are now producing panels of potential biomarker candidates for diagnosis or prognosis. However, clinical validation and implementation of these biomarkers remain limited by the reliance on dated triple quadrupol...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-17 | MSV000095051 | MassIVE
ProteomicsDifferential UBE2H-CTLH E2-E3 ubiquitylation modulesregulate erythroid maturation
The developmentof haematopoietic stem cellsinto mature erythrocytes–erythropoiesis –is a controlled process characterized by cellular reorganisation and drastic reshaping of the proteome landscape.Failure of ordered erythropoiesis isassociated with anaemias and haematological maligna...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031992 | Pride
Ube2h Proteomics Dia Ms Gid complex Ubiquitination E2 Ctlh complex E3 
ProteomicsProfiling of the human intestinal microbiome and bile acids under physiologic conditions using an ingestible sampling device
The spatiotemporal structure of the human microbiome, proteome, and metabolome reflects and determines regional intestinal physiology and may have implications for disease. Yet, we know little about the distribution of microbes, their environment, and their biochemical activity in the gut because of...
ORGANISM(S): Homo sapiens (Human) 
2023-01-18 | PXD038906 | Pride
Sampling device Human Gut Spatiotemporal Intenstine Microbiome 
UnknownC-terminal lysine residues localise NLRP10 at lipid droplets and govern NLRP10 oligomer formation
Not available
S-SCDT-10_1038-S44319-026-00839-9 | biostudies-other
ProteomicsHYPK affects proteostasis by facilitating co-translational imprinting of the proteome with acetylation marks
N-terminal acetylation is one of the most common protein modifications in eukaryotes. The NatA complex is the dominant regulator of the N-acetylome in all eukaryotes. The Huntingtin yeast partner K (HYPK) physically interacts with the NatA/NAA50 comples in metazoan and we describe HYPK as a critical...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-04-13 | PXD022120 | Pride
N-terminal acetylation 
ProteomicsCrosslinking-MS dataset of the TFIIIC subcomplex tauA with Brf1 and TBP
Identification of crosslinks between the subunits tau131, tau95, tau55, Brf1 and TBP
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-12-04 | PXD018232 | Pride
Tfiiib Pol iii Tfiiic Xl-ms Transcription S. cerevisiae 
MetabolomicsGenome-scale metabolic modelling of responses to polymyxins in Pseudomonas aeruginosa
Background: Pseudomonas aeruginosa often causes multidrug-resistant infections in immunocompromised patients and polymyxins are often used as the last-line therapy. Alarmingly, resistance to polymyxins has been increasingly reported worldwide recently. To rescue this last-resort class of antibiotics...
2018-02-28 | MTBLS630 | MetaboLights
TranscriptomicsBMP9_BMPR2_PAEC_BOEC
Human pulmonary arterial endothelial cells (PAECs) and blood outgrowth endothelial cells (BOECs) from healthy subjects were stimulated with BMP9, BMP2 or BMP6. and assessed for changes in gene transcription by microarray. Unlike BMP2 and BMP6, which had negligible impacts on gene expression, BMP9 in...
ORGANISM(S): Homo sapiens 
2015-06-15 | E-MTAB-2495 | biostudies-arrayexpress
Sort   by:  
 Page size