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ProteomicsDeciphering the dynamic proteome of multiciliated cells
Multiciliated cells (MCCs) are essential for generating directional fluid flow across specialized epithelia in various vertebrate organs. MCC differentiation involves a unique, tightly regulated program characterized by massive centriole amplification, independently of DNA replication. Although much...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2026-02-06 | PXD064476 | Pride
Lc-msms Multiciliated cells proteome (mcc) Deuterosome Centriole Xenopus 
ProteomicsIdentification of CDC20/CDC20B partners in HEK cells demonstrates that CDC20, but not CDC20B, interacts with multiple APC/C components
Multiciliated cells (MCCs) harbour dozens to hundreds of motile cilia, which beat in a synchronized and directional manner, thus generating hydrodynamic forces important in animal physiology. In vertebrates, MCC differentiation critically depends on the synthesis and release of numerous centrioles b...
ORGANISM(S): Homo sapiens (Human) 
2019-04-03 | PXD010629 | Pride
Motile cilia Deuterosome Centriole Plk1 Cdc20b Separase Cdc20 Cell cycle Hek cells 
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