Sort   by:  
 Page size 
MetabolomicsDissection of two routes to naïve pluripotency using different kinase inhibitors
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
ProteomicsMASS SPECTROMETRY ROADMAPS TO NAIVE PLURIPOTENCY
Pluripotency can be maintained in the naïve state through manipulation of ERK and WNT signalling (2i), shielding embryonic stem cells (ESCs) from inductive cues. Alternatively, inhibiting CDK8/19 (CDK8/19i), a repressor of the Mediator co-activator complex, directly stimulates super-enhancer activit...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-10 | PXD018694 | Pride
Phosphoproteomics Mouse stem cells Proteomics 
ProteomicsON THE ACCURACY, PRECISION AND STATISTICAL SIGNIFICANCE OF COMPRESSED RATIOS IN ISOBARIC LABELLING
Despite the outstanding advantages that isobaric labelling has to offer in quantitative proteomics, its precision and accuracy are undermined by ratio compression, which is consequence of the co-isolation of peptides within a selected isolation window. Here, using the two-proteomes approach we inves...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2016-08-08 | PXD003640 | Pride
Isobaric labelling Statistics Accuracy Ratio compression Precision 
ProteomicsPHD3 and FIH substrates cluster in distinct signalling pathways
Amino acid hydroxylation is a common post-translational modification which regulates intra and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate (2OG) dependent enzymes and although the biochemistry is well understood, until now only a few su...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080766 | MassIVE
UnknownQuality improvement collaborative for improving patient care delivery in Argentine public health sector intensive care units.
Not available
S-EPMC11149125 | biostudies-literature
UnknownCardiac troponin and COVID-19 severity: Results from BIOCOVID study.
Not available
S-EPMC7995181 | biostudies-literature
UnknownOccurrence of SARS-CoV-2 viremia is associated with genetic variants of genes related to COVID-19 pathogenesis.
Not available
S-EPMC10557488 | biostudies-literature
UnknownHeterogeneity in the association between prediabetes categories and reduction on glomerular filtration rate in a 5-year follow-up.
Not available
S-EPMC9072306 | biostudies-literature
UnknownD-Dimer in Acute Mesenteric Venous Thrombosis: A Prospective Case-Control International Multicenter Study.
Not available
S-EPMC11590162 | biostudies-literature
UnknownImpact of neuromuscular block monitoring and reversal on postoperative pulmonary complications in thoracic surgery: a Bayesian analysis of the iPROVE-OLV trial.
Not available
S-EPMC12597387 | biostudies-literature
Sort   by:  
 Page size