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ProteomicsStructure of Saccharomyces cerevisiae Mediator-RNA polymerase II pre-initiation complex for divergent transcription
This study has determined structure of transcription initiation complexes including a DNA-bound activator, RNA polymerase II (Pol II), and Mediator on a divergent promoter GAL80/SUT719 using a combination of cryo-EM and XL-MS analyses. Our cryo-EM single-particle analysis reveals a dimeric form of ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-05-22 | PXD036149 | Pride
Enhancer Divergent transcription Transcription Mediator Uas Initiation Activator Rna polymerase ii 
ProteomicsStructural basis of the human transcriptional Mediator complex modulated by its dissociable Kinase module
The Mediator complex consists of a Core and a dissociable Kinase module. This project is to understand the binding mode between the Core and Kinase module. Both Mediator complex and its Kinase module were individually crosslinked and analyzed by XL-MS.
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD044328 | Pride
Human Transcription Mediator Cdk8 
ProteomicsPRR of Tau Crosslinking with Tubulin
We used cross-linking mass spectrometry with the cleavable cross-linker, disuccinimidyl dibutyric urea (DSBU) to map sites of interaction between the proline rich domain (PRR, tau amino acids 149-244) and tubulin. For comparison, we also conducted these experiments with PRR constructs containing mul...
ORGANISM(S): Bos taurus (Bovine) Escherichia coli 
2026-03-09 | PXD049384 | Pride
Tubulin Tau Phosphorylation Proline rich region 
UnknownBrefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3) is predicted to interact with its partner through an ARM-type α-helical structure.
Not available
S-EPMC4096751 | biostudies-literature
UnknownStructural basis of a transcription pre-initiation complex on a divergent promoter
Not available
EMPIAR-11284 | biostudies-other
UnknownStructural basis of a transcription pre-initiation complex on a divergent promoter
Not available
EMPIAR-11293 | biostudies-other
UnknownStructural visualization of de novo initiation of RNA polymerase II transcription
Not available
EMPIAR-10865 | biostudies-other
UnknownCryo-EM structures of engineered active bc1-cbb3 type CIII2CIV super-complexes and electronic communication between the complexes
Not available
EMPIAR-10735 | biostudies-other
UnknownComprehensive analysis of gut microbiota of a healthy population and covariates affecting microbial variation in two large Japanese cohorts.
Not available
S-EPMC8139087 | biostudies-literature
ProteomicsIdentification of novel biomarkers for aortic aneurysm
To discover novel biomarkers for aortic aneurysm, serum samples of patients with thoracic aortic aneurysm were fractionated, tryptic digested, and subjected to proteome analysis.
ORGANISM(S): Homo Sapiens (human) 
2023-11-15 | PXD033774 | JPOST Repository
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