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MetabolomicsMulti-Omics profiling reveals immunometabolic adaptations underlying disease resilience in indigenous Lueyang Silky Fowl compared to White Leghorns
Sustainable avian production demands genetic strategies beyond vaccines to enhance disease resilience, particularly in indigenous breeds like Lueyang Silky Fowl (LSF), which show superior resistance compared to commercial White Leghorn chickens (WLC) but lack molecular characterization. We hypothesi...
2026-05-27 | MTBLS14590 | MetaboLights
TranscriptomicsTranscription profiling of normal adult rat extraocular muscle, cardiac muscle, leg (gastrocnemius-soleus) muscle and smooth muscle (stomach wall)
Comparison of normal adult rat extraocular muscle, cardiac muscle, leg (gastrocnemius-soleus) muscle and smooth muscle (stomach wall). Affymetrix microarray chip RG-U34A was used. MAS version 5 was used to analyze the muscle group differences. Data form part of publication: FASEB Journal 17: 1370-...
ORGANISM(S): Rattus norvegicus 
2007-10-27 | E-GEOD-142 | biostudies-arrayexpress
ProteomicsHistamine mediates food intake, but not muscle adaptations, following 10 weeks of resistance training in humans
Histamine receptor antagonists, commonly used to treat allergies, block histamine signalling and have been shown to impair acute and chronic adaptations to high-intensity and endurance-type exercise. Since it remains unclear whether this is a universal mechanism of muscle adaptation, this study inve...
ORGANISM(S): Homo sapiens (Human) 
2026-03-04 | PXD064353 | Pride
Fat mass Resistance training Food intake Muscle adaptations H1 antihistamines Histamine 
TranscriptomicsmRNA Sequencing of skeletal muscle genes in wildtype and BCATm (BCAT2) KO mice
Consumption of a protein containing meal by a fasted animal promotes protein accretion in skeletal muscle, in part through leucine stimulation of protein synthesis and indirectly through repression of protein degradation mediated by its metabolite, α-ketoisocaproate. Mice lacking the mitochondrial ...
ORGANISM(S): Mus musculus 
2015-12-11 | E-GEOD-68915 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of human skeletal muscle cell line AB1167, with groups of PRDX2 KD, treated with electrical stimulation and both 2.5 and 5uM H202 for 15 minutes
This study investigates the role of peroxiredoxin 2 (PRDX2) in mediating oxidative adaptations in human skeletal muscle myotubes subjected to mechanical contraction and hydrogen peroxide (H2O2) exposure. additionally, the effect of an electrical stimulation protocol was assessed pre and post PRDX2 K...
ORGANISM(S): Homo sapiens 
2025-01-01 | E-MTAB-14577 | biostudies-arrayexpress
ProteomicsErk3 deletion drives oxidative adaptations in skeletal muscle
Skeletal muscle plays a central role in whole-body energy expenditure and metabolic homeostasis, and improving its mitochondrial function and oxidative fiber profile is considered an effective strategy to counteract diet-induced metabolic impairments, although the molecular regulators of these adapt...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD074086 | Pride
Ekr3 mk5 muscle 
ProteomicsGlobal proteomics reveals distinct muscle adaptations to menstrual cycle phase-based sprint interval training in endurance-trained females
Advances in mass-spectrometry (MS)-based technologies have leveraged our understanding of protein-wide adaptations in human skeletal muscle in response to exercise. However, there is a lack of such data in females, particularly pertaining to already trained females and menstrual cycle phase-based sp...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD051852 | Pride
Human Muscle Training Menstrual cycle Lc-ms/ms 
TranscriptomicsA transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype (resting muscle after endurance training)
The molecular pathways which are activated and contribute to physiological remodeling of skeletal muscle in response to endurance exercise have not been fully characterized. We previously reported that ~800 gene transcripts are regulated following 6 weeks of supervised endurance training in young se...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-35659 | biostudies-arrayexpress
TranscriptomicsShort-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice
The prevalence of the metabolic syndrome (MS) is rapidly increasing all over the world. Consequently, there is an urgent need for more effective intervention strategies. Both animal and human studies indicate that lipid oversupply to skeletal muscle can result in insulin resistance which is one of t...
ORGANISM(S): Mus musculus 
2007-11-30 | E-GEOD-8524 | biostudies-arrayexpress
GenomicsErk3 deletion drives oxidative adaptations in skeletal muscle
Erk3 deletion drives oxidative adaptations in skeletal muscle
PRJNA1425585 | ENA
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