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MetabolomicsMetabolomic changes in Mycobacterium avium subsp. paratuberculosis (MAP) challenged Holstein-Friesian cattle suggest the role of serum amino acids as indicators of immune system activation

INTRODUCTION: Paratuberculosis, commonly known as Johne’s disease, is a chronic intestinal infection of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP). Clinical signs, including reduced milk yields, weight loss and diarrhoea, are typically abse...

2022-02-23 | MTBLS2963 | MetaboLights
TranscriptomicsComparative genomic hybridizations of Mycobacterium avium isolates obtained from multiple host species
A comparative genomic approach was used to identify large sequence polymorphisms among Mycobacterium avium isolates obtained from a variety of host species. DNA microarrays were used as a platform for comparing mycobacteria field isolates with the sequenced bovine isolate Mycobacterium avium subsp....
ORGANISM(S): Mycobacterium avium 
2010-06-11 | E-GEOD-7622 | biostudies-arrayexpress
TranscriptomicsBovine Peyer's Patch Infected with Mycobacterium avium ssp. paratuberculosis and Mycobacterium avium ssp. avium
Mycobacterium avium subspecies paratuberculosis (MAP) infection is established following the ingestion of bacteria, their penetration of the intestinal mucosa and subsequent events of the host-parasite interaction. These bacteria invade M cells, macrophages and are capable of resisting host defenses...
ORGANISM(S): Bos taurus 
2012-10-03 | E-GEOD-13888 | biostudies-arrayexpress
TranscriptomicsMycobacterium avium subsp. paratuberculosis gene transcription in simulated phagosomal environment and in human macrophage infection
This SuperSeries is composed of the following subset Series: GSE32241: Differentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro acid-nitrosative multi-stress GSE32242: Differentially regulated genes induced in Mycobacterium avium subspecies paratuberculos...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis 
2012-05-31 | E-GEOD-32243 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of Mycobacterium avium TMC724 vs. M. avium 104 non-coding and coding transcriptome
Deep sequencing was implemented to study the transcriptional landscape of Mycobacterium avium TMC724. High-resolution transcriptome analysis identified the transcription start points for 652 genes. One third of these coincided with the start codons and therefore belong to leaderless transcripts, whe...
ORGANISM(S): Mycobacterium avium 
2013-04-23 | E-GEOD-46281 | biostudies-arrayexpress
ProteomicsNovel Events, Gene Model Correction of Mycobacterium Avium by Proteogenomic Analysis
Mycobacterium avium is one of the prominent disease causing bacteria in humans. It causes lymphadenitis, chronic pulmonary and extrapulmonary and disseminated infections in adults, children and immunocompromised humans. M. avium has ~4,500 predicted gene models, out of which not all are identified a...
ORGANISM(S): Mycobacterium avium 104 
2023-03-17 | PXD032067 | Pride
Dia Mycobacterium avium Proteogenomics Variant calling Dda Lc-ms/ms 
TranscriptomicsDifferentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro acid-nitrosative multi-stress
Transcriptional profile of Mycobacterium avium subspecies paratuberculosis in in vitro acid-nitrosative multistress, comparing untreated control cells and bacteria under multi-stress. Two-condition experiment, MAP-K vs. MAP-ACID-NO treated. Biological replicates: 3 controls, 3 Acid-NO treated, indep...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis 
2012-05-31 | E-GEOD-32241 | biostudies-arrayexpress
TranscriptomicsDifferentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro infection of THP-1 human macrophage cell line
Transcriptional profile of Mycobacterium avium subspecies paratuberculosis in in vitro THP-1 (ATCC TIB-202) cell line infection, comparing bacteria grown in host medium and intracellular bacteria recovered from infected THP-1 cells. Two-condition experiment, MAP-K vs. intracellular MAP-THP-1. Biolog...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis 
2012-05-31 | E-GEOD-32242 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Mycobacterium avium subspecies paratuberculosis treated with rhodanine agent D157070
Data is also available from BuG@Sbase
ORGANISM(S): Mycobacterium avium 
2010-03-03 | E-BUGS-92 | biostudies-arrayexpress
ProteomicsLabel-free quantitative proteomic analysis of Mycobacterium avium hominissuis
The objective of this study is to investigate the protein expression level difference between Mycobacterium avium hominissuis wild type strain MAH-104 , its mutant 21m (gene lysX (MAV_3128) mutated - Lysyl tRNA synthetase) and the complemented strain 21c (MAV_3128comp) using liquid chromatography-...
ORGANISM(S): Mycobacterium avium complex Mycobacterium avium subsp. hominissuis 
2018-02-26 | PXD006470 | Pride
Label free quantitative analysis Proteomic analysis Mutant Perseus software Mycobacterium avium hominissuis Maxquant-andromeda Ltq orbitrap velos mass spectrometer Maxquant software 
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