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TranscriptomicsAberrant DNA methylation profiling of classic Philadelphia Negative Myeloproliferative Neoplasms
Since most DNA methylation studies in Classic Philadelphia-negative myeloproliferative neoplasms (MPNs) M-bM-^@M-^S polycythaemia vera (PV), essential thrombocythaemia (ET), and primary myelofibrosis (PMF) - have been performed on a gene-by-gene basis, a more comprehensive methylation profiling is n...
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-42042 | biostudies-arrayexpress
TranscriptomicsMyelodysplastic/myeloproliferative neoplasms
This SuperSeries is composed of the following subset Series: GSE21948: High Density custom Agilent 44K CGH array analysis of 7q and TET2 region in myelodysplastic/myeloproliferative neoplasms GSE21990: Affymetrix SNP 6.0 array data for myelodysplastic/myeloproliferative neoplasms Refer to individual...
ORGANISM(S): Homo sapiens 
2010-06-30 | E-GEOD-21991 | biostudies-arrayexpress
TranscriptomicsGenetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predispose to myeloproliferative neoplasms
Genome-wide association study of JAK2 V617F negative myeloproliferative neoplasms consisting of 524 cases at stage 1
ORGANISM(S): Homo sapiens 
2015-02-20 | E-MTAB-3340 | biostudies-arrayexpress
TranscriptomicsSingle cell long read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AML
Myeloproliferative neoplasm (MPN) or post-MPN acute myeloid leukemia patient bone marrow aspirates were sorted for CD34+ hematopoietic stem and progenitor cells (HSPCs), followed by 10x 3' single cell RNA sequencing and long read sequencing to study the consequences of mutation combination on HSPCs.
ORGANISM(S): Homo sapiens 
2026-06-25 | E-MTAB-15981 | biostudies-arrayexpress
ProteomicsPathophysiology of arterial cardiovascular events in patients with JAK2V617F myeloproliferative neoplasms
Cardiovascular events are the leading cause of death in patients with JAK2V617F myeloproliferative neoplasms. Their mechanisms are poorly understood. To investigate the role of microvesicles in these events, we performed a proteomic analysis of microvesicles derived from red blood cells from mice w...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD014451 | Pride
Red blood cells Myeloproliferative neoplasms Mouse Microvesicles Jak2v617f 
ProteomicsPlatelet Proteome in Myeloproliferative Neoplasms
Patients with chronic Myeloproliferative Neoplasms (MPN) including polycythaemia vera (PV) and essential thrombocythemia (ET) exhibit unique clinical features, such as a tendency toward thrombosis and hemorrhage, and risk of disease progression to secondary bone marrow fibrosis and/or acute leukemia...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD046324 | Pride
Platelet Bruker timstof Data dependant acquisition Mpn Myeloproliferative neoplasms 
ModelsTalarmain2022- Model of JAK2/TET2/HOXA9 in myeloproliferative neoplasms
Model describing how HOXA9 may control the evolution of myeloproliferative neoplasms by integrating the orders of JAK2 and TET2 mutation
2023-03-17 | MODEL2212110001 | BioModels
TranscriptomicsHigh Density custom Agilent 44K CGH array analysis of 7q and TET2 region in myelodysplastic/myeloproliferative neoplasms
Abnormalities of chromosome 7q are common in myeloid malignancies. Agilent CGH arrays targeted to 7q and Affymetrix SNP 6.0 arrays were used to characterise 7q aUPD and deletions. Sample #017 in this data series showed a microdeletion encompassing EZH2. Screening of a total of 614 cases with myeloid...
ORGANISM(S): Homo sapiens 
2010-06-30 | E-GEOD-21948 | biostudies-arrayexpress
ProteomicsTargeting CHAF1B enhances interferon activity in myeloproliferative neoplasms
Interferons (IFNs) are cytokines with potent anti-neoplastic properties and significant clinical activity in the treatment of myeloproliferative neoplasms (MPNs). The use of pegylated IFN for the treatment of MPNs has been of particular interest, with several clinical trials establishing clinical r...
ORGANISM(S): Homo sapiens (Human) 
2023-05-15 | PXD037376 | Pride
Chaf1b Myeloproliferative neoplasms Interferon 
GenomicsEvolution of the cancer epigenome in myeloproliferative neoplasms
Evolution of the cancer epigenome in myeloproliferative neoplasms.
EGAS00001001941 | EGA
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