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TranscriptomicsTranscription profiling of human soluble guanylate cyclase-deficient U937 cells exposed to the nitric oxide (NO) donor S-nitrosoglutathione to provide insight into the cGMP-independent effects of NO
NO effects on gene expression, independent of cGMP, were examined globally. Differentiated human U937 cells that lack soluble guanylate cyclase were exposed to Snitrosoglutathione, a NO donor, or glutathione without or with dibutyryl-cAMP (Bt2cAMP). NO regulated 110 transcripts that annotated dispro...
ORGANISM(S): Homo sapiens 
2007-09-11 | E-GEOD-2649 | biostudies-arrayexpress
UnknownDisease activity and patient-reported outcomes in patients with rheumatoid arthritis and Sjogren's syndrome enrolled in a large observational US registry.
Not available
S-EPMC7316680 | biostudies-literature
UnknownEvaluation of a PEGylated Fibroblast Growth Factor 21 Variant Using Novel Preclinical Magnetic Resonance Imaging and Magnetic Resonance Elastography in a Mouse Model of Nonalcoholic Steatohepatitis.
Not available
S-EPMC9533307 | biostudies-literature
UnknownThe Transcriptome of Paired Major and Minor Salivary Gland Tissue in Patients With Primary Sjogren's Syndrome.
Not available
S-EPMC8291032 | biostudies-literature
TranscriptomicsmRNA abundance in HEK293T cells mock or miR-124 transfected
HEK293T cells were either mock or miR-124 transfected. Cells were lysed 12 hours after transfection with Trizol reagent. RNA was isolated, amplified, labeled (cy5), and comparatively hybridized with a universal reference (cy3) on HEEBO arrays in biological triplicate. In addition, each biological re...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-18835 | biostudies-arrayexpress
UnknownEfficacy and safety of abatacept in active primary Sjogren's syndrome: results of a phase III, randomised, placebo-controlled trial.
Not available
S-EPMC7892395 | biostudies-literature
UnknownA Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.
Not available
S-EPMC5924706 | biostudies-literature
UnknownLisocabtagene maraleucel in chronic lymphocytic leukaemia and small lymphocytic lymphoma (TRANSCEND CLL 004): a multicentre, open-label, single-arm, phase 1-2 study.
Not available
S-EPMC11753452 | biostudies-literature
ProteomicsA Structural Mechanism for Noncanonical GPCR Signal Transduction in the Hedgehog Pathway
The Hedgehog (Hh) signaling pathway is fundamental to embryogenesis, tissue homeostasis, and cancer. Hh signals are transduced via an unusual mechanism: upon agonist-induced phosphorylation, the noncanonical G protein-coupled receptor SMOOTHENED (SMO) binds the catalytic subunit of protein kinase A ...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-26 | PXD067578 | Pride
Smoothened Protein kinase a Hedgehog 
UnknownSalivary Gland Stem Cells Age Prematurely in Primary Sjogren's Syndrome.
Not available
S-EPMC6607019 | biostudies-literature
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