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ProteomicsN-Terminal Sequence Analysis of Protein PfpC in MPAO1
N-Terminal Sequence Analysis was used to detect the degradation of Protein PfpC in Pseudomonas aeruginosaMPAO1.
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2025-07-01 | PXD059573 | Pride
N-terminal sequence 
TranscriptomicsGenome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting
So far, the annotation of translation initiation sites (TISs) has been based mostly upon bioinformatics rather than experimental evidence. We adapted ribosomal footprinting to puromycin-treated cells to generate a transcriptome-wide map of TISs in a human monocytic cell line. A neural network was tr...
ORGANISM(S): Homo sapiens 
2012-08-08 | E-GEOD-39561 | biostudies-arrayexpress
ProteomicsDiscovering the N-terminal Methylome by the Repurposing of Proteomic Datasets
Protein ⍺-N-methylation is a cryptic and relatively unexplored post-translational modification involving the covalent addition of methyl groups to the free a-amino group at protein N-termini. To systematically explore the extent of ⍺-N-terminal methylation in yeast and humans, we utilized a repurpos...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-05-26 | PXD022833 | Pride
Proteomics Post-translational modification Repurposing ⍺-n-terminal methylation 
ProteomicsN-terminal acetylome analyses reveals the substrate specificity profile of Naa50 (Nat5) and implicate NATs in influencing initiator Methionine processing
Co-translational N-terminal (Nt-) acetylation of nascent polypeptides is catalyzed by N-terminal acetyltransferases (NATs). The very N-terminal amino acid sequence is the major factor determining whether or not a given protein is Nt-acetylated. In humans, six different NATs, denoted NatA-NatF, are i...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-05-29 | PXD001437 | Pride
N-terminal acetyltransferase / n-terminomics / nt-acetylome / naa50 / nate 
ProteomicsOverlap of NatA and IAP substrates implicates N-terminal acetyltion in protein stabilization
SMAC/DIABLO and HTRA2 are mitochondrial proteins whose N-termina sequences, known as inhibitor of apoptosis binding motifs (IBMs), bind and activate ubiquitin ligases knwon as inhibitor of apoptosis proteins (IAPs), unleashing a cell´s poteintial.IBMs comprise a 4-residue, loose consensus sequence, ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021815 | Pride
N-terminal acetylation Birc3 Birc2 Natb N-terminomics Nata Apoptosis Xiap N-degron 
TranscriptomicsExpression profiling in primary embryonic fibroblasts deficient for the N-terminal truncation of Lats1
Lats1 and Lats2 are the mediators of the Hippo pathway that regulates tissue growth and proliferation. Lats1 and Lats2 kinases share 85% sequence identity in the kinase domain. However, their non-kinase regions at the N-terminus are distinct except for Lats conserved domain 1 (LCD1) and LCD2, sugges...
ORGANISM(S): Mus musculus 
2012-12-17 | E-GEOD-37871 | biostudies-arrayexpress
ProteomicsArabidopsis thaliana N-terminal proteome,LC-MS
An extended ChaFRADIC workflow was applied to analyze the N-terminal proteome of Arabidopsis thaliana seedlings. Using iTRAQ protein labeling, a multi-enzyme digestion approach including trypsin, GluC, and subtilisin, a total of 200 μg per enzyme were used, and only 1/3 of each ChaFRADIC-enriched fr...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2015-07-21 | PXD001855 | Pride
Arabidopsis thaliana Chafradic Itraq reagent Enrichment of n-terminal peptide 
ProteomicsDeveloping a Novel and Integrative Method to Systematically Investigate the Stability of N-Terminal Proteoforms
Protein N-terminal proteoforms, which include both N-terminal modifications and sequence variation arising from processes such as proteolytic cleavage, are common in cells and have been reported to significantly impact protein stability. Systematically examining the correlation between these N-termi...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD057760 | Pride
Thermal proteome profiling N-terminal acetylation N-terminome Thermal stability difference Terminal amine isotopic labeling of substrates Tails Tpp N-terminal proteoform 
ProteomicsFunction of the histone N-terminal acetyltransferase Naa40 in DNA damage response
N-alpha-acetyltransferase 40 (NAA40) catalyzes acetylation on the N-terminal tip of histones H4 (N-acH4) and H2A (N-acH2A) harboring the Ser(1)-Gly(2)-Arg(3)-Gly(4) recognition sequence. In addition to the well-known role of N-terminal acetylation in protein degradation and stability, recent studies...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD050981 | Pride
Histone post-translational modifications Histone n-terminal acetylation 
Proteomics5′ UTR length regulates the production of alternative N-terminal protein isoforms in health and disease
The 5′ untranslated region (5′ UTR) of an mRNA is classically viewed as a regulatory region that controls the amount of protein production, but not the resulting protein sequence. Here, we demonstrate that 5′ UTR length also plays a direct role in alternative N-terminal protein isoform production by...
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD073007 | Pride
Cfd Translation initiation Alternative n-terminal isoform 
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