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UnknownPerformance comparisons of nano-LC systems, electrospray sources and LC-MS-MS platforms.
Not available
S-EPMC3886563 | biostudies-literature
ProteomicsProtein S-glutathionylation in HeLa cells identified by nanoLC-LTQ-Orbitrap XL MS/MS
Cysteine modifications have been widely detected among different protein in different species. Here, we examined protein glutathionylation in HeLa cells under both untreated and diamide-treated conditions. A strategy using resin-assisted enrichment of glutathionylated proteins or peptides after biot...
ORGANISM(S): Homo sapiens (Human) 
2020-04-29 | PXD017717 | Pride
Nanolc-ltq-orbitrap xl ms/ms Biotin switch S-glutathionylation 
UnknownImproving proteome coverage on a LTQ-Orbitrap using design of experiments.
Not available
S-EPMC3145359 | biostudies-literature
ProteomicsTemporal phosphoproteomic analysis of VEGF-A signaling in HUVECs: An insight into early signaling events associated with angiogenesis
Aim of the study was to elucidate the phosphoproteomics alterations caused by the treatment of VEGF-A in HUVEC cells at early timepoints of 1, 5 and 10 minutes. Label-free quantitative temporal phosphoproteomics experiments were carried out using LC-MS/MS methods. LTQ orbitrap XL ETD (Thermo Electro...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD038133 | Pride
Angiogenesis Vegf-a Cytoskeleton organization Quantitative phosphoproteomics 
UnknownThe proteome of mouse cerebral arteries.
Not available
S-EPMC4050249 | biostudies-literature
ProteomicsQuantitative proteomics of IBMX-induced neuron differentiation from placenta-derived multipotent stem cells
placenta-derived multipotent stem cells (PDMC) were stimulated by IBMX to differentiated into neuronal-like cells. The cells were lyzed, trypsin digested, and dimethyl labled, followed by strong cation exchange fractionation. The peptides were analyzed by nanoLC-MS/MS with Thermo LTQ-Orbitrap XL. Pr...
ORGANISM(S): Homo Sapiens (human) 
2021-08-14 | PXD016085 | JPOST Repository
UnknownSemi-quantitative analysis of changes in the plasma peptidome of Manduca sexta larvae and their correlation with the transcriptome variations upon immune challenge.
Not available
S-EPMC3992937 | biostudies-literature
ProteomicsEffects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation
The association between kidney stone disease and renal fibrosis has been widely explored in recent years but its underlying mechanisms remain far from complete understanding. Using label-free quantitative proteomics (nanoLC-ESI-LTQ-Orbitrap MS/MS), this study identified 23 significantly altered secr...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD027039 | Pride
Calcium oxalate  kidney stone  macrophage  renal fibrosis  secretome 
ProteomicsOxidative modifications of urinary proteins increase kidney stone risk
Clinical and animal studies have demonstrated the increasing evidence of oxidative stress in kidney stone disease. Recent findings have shown that the interactions between calcium oxalate (CaOx) crystals and renal tubular cells can promote many cellular events such as cell proliferation, cell death,...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD019360 | Pride
Calcium oxalate  kidney stone  oxidative stress  post-translation modification  uromodulin 
ProteomicsQuantitative proteomics reveals common and unique molecular mechanisms underlying beneficial effects of caffeine and trigonelline on human hepatocytes
Caffeine and trigonelline are the major bioactive compounds in coffee. Caffeine alone or combined with other coffee compounds shows hepatoprotective effects. However, molecular mechanisms underlying such hepatoprotective effects remain unclear. We therefore addressed molecular effects of caffeine an...
ORGANISM(S): Homo sapiens (Human) 
2023-12-05 | PXD037553 | Pride
Coffee  hepatoprotection  hepg2  protein synthesis  ribosome  translation 
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