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TranscriptomicsTranscription profiling of human umbilical vein endothelial cells (HUVEC) treated with VEGF-A
Angiogenesis, the formation of new capillaries by sprouting from preexisting vessels, is mainly induced by VEGF-A. To identify genes which are induced by VEGF-A in endothelial cells, HUVEC were starved and induced by VEGF-A165 for 30, 60 and 150min. RNA of induced and uninduced cells was isolated an...
ORGANISM(S): Homo sapiens 
2009-10-20 | E-GEOD-15464 | biostudies-arrayexpress
GenomicsControl of VEGF-A trancriptional programs by pausing and genomic compartmentalization
Vascular endothelial growth factor A (VEGF-A) is a master regulator of vascular development and function. Consequently, VEGF-A regulated gene expression programs have been under heavy research. In this study we study the transcriptional regulation of VEGF-A-responsive genes in primary aortic endothe...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-52642 | biostudies-arrayexpress
TranscriptomicsA compact VEGF signature associated with distant metastases and poor outcomes
Results When compared with each other, primary tumors and regional metastases showed statistically indistinguishable gene expression patterns. Supervised analyses comparing patients with distant metastases versus primary tumors or regional metastases showed that the distant metastases were distinct...
ORGANISM(S): Homo sapiens 
2009-03-31 | E-GEOD-3521 | biostudies-arrayexpress
ProteomicsVEGF orchestration of the p130Cas Interactome
p130Cas is a polyvalent adapter protein essential for cardiovascular development, and with a key role in cell movement. In order to identify the pathways by which p130Cas exerts its biological functions in endothelial cells we mapped the p130Cas interactome and its dynamic changes in response to VEG...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080860 | MassIVE
TranscriptomicsVEGF-A stimulated gene expression in human liver sinusoidal endothelial cells
Transcriptomic analysis of VEGF-A stimulated liver sinusoidal endothelial cell gene expression. Untreated cells were compared to those treated with VEGF-A. VEGF-A stimulation is critical for normal LSEC phenotype, and the response to liver injury Two conditions: untreated vs. VEGF-A treated. LSEC...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-41110 | biostudies-arrayexpress
TranscriptomicsOff-target effects of VEGF-A regulation by shRNAs
The aim of this project was to investigate how genome-wide gene expression patterns change when the expression of VEGF-A is modulated using different lentivirally delivered shRNA molecules that are complementary to VEGF-A promoter region. To study these changes, 12 gene expression array experiments ...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-47444 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human umbilical vein endothelial cells (HUVECs) stimulated with recombinant Vascular Endothelial Growth Factor A (VEGF-A) against untreated control
In order to identify new genes potentially involved in angiogenesis process, we performed a deep-sequencing transcriptome analysis of HUVECs stimulated with recombinant VEGF-A, introducing a difference with respect to the several previous studies. Primary ECs are normally cultured in vitro using an ...
ORGANISM(S): Homo sapiens 
2021-04-08 | E-MTAB-9337 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HCT116 clones stably expressing vegf 5 prime UTR reveals a novel tumor promoting function
VEGF165 is one of the key regulators of tumor development. Using HCT116 cells transfected with full-length vegf mRNA, full-length vegf mRNA with mutations of H9D and L14E, mutated vegf mRNAs lacking untranslated regions (UTRs), and 5â??UTR mutated between nt 591 and nt 746, we found that vegf 5â??UT...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8888 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat aortic rings treated with angiopoietin-1, VEGF or untreated
Specific Aims ; To identify novel transcriptional events associated with angiogenesis in VEGF and Ang-1 stimulated rat aortic rings. Our studies take advantage of the capacity of rat aortic rings to generate new vessels in collagen gels. Rat aortic rings embedded in collagen gel immediately after e...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-3355 | biostudies-arrayexpress
ProteomicsTemporal phosphoproteomic analysis of VEGF-A signaling in HUVECs: An insight into early signaling events associated with angiogenesis
Aim of the study was to elucidate the phosphoproteomics alterations caused by the treatment of VEGF-A in HUVEC cells at early timepoints of 1, 5 and 10 minutes. Label-free quantitative temporal phosphoproteomics experiments were carried out using LC-MS/MS methods. LTQ orbitrap XL ETD (Thermo Electro...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD038133 | Pride
Angiogenesis Vegf-a Cytoskeleton organization Quantitative phosphoproteomics 
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