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MetabolomicsThe nasal microbiome and metabolites are altered in depression patients
Depressive disorder is a heterogeneous neuropsychiatric disorder. It affects millions of people worldwide. The exact causes of depressive behavior remain unclear and are believed to implicate both genetic and environmental factors. In the past decade, there have been numerous studies on the dysbiosi...
2025-07-21 | MTBLS10742 | MetaboLights
MetabolomicsCharacterizing the nasal metabolome and exposome by LC-HRMS: Opportunities and challenges

The nasal cavity represents a host-microbial interface critical to respiratory defense against viral infections, including those caused by influenza virus, respiratory syncytial virus, rhinovirus or SARS-CoV-2. Although the nasal microbiome itself has been well characterized, the nasal metabolome...

2026-10-22 | MTBLS14409 | MetaboLights
MetabolomicsCharacterization of the nasal microbiome and metabolome in children with Henoch-Schonlein purpura and children with Henoch-Schonlein purpura nephritis

Three groups of eligible subjects were included, including 20 cases in the HSP group, 20 cases in the HSPN group, and 20 cases in the healthy control (HC) group. Nasal lavage samples from each group were subjected to 16SrRNA gene sequencing and metabolomic analyses to screen differential flora an...

2026-04-11 | MTBLS12590 | MetaboLights
MetabolomicsCholic Acid as a Potential Mediator in PD Olfactory Dysfunction: Insights from Nasal Microbiome-Metabolite Interactions Research

Background: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by both motor and non-motor symptoms, including olfactory dysfunction, which often precedes motor symptoms by several years. However, the underlying mechanisms linking olfactory dysfunction in PD to bio...

2025-07-07 | MTBLS12692 | MetaboLights
ProteomicsIn-depth proteomic analysis of nasal fluids from patients with chronic rhinosinusitis and nasal polyps by data-independent acqusition
Antibiotics are commonly prescribed to treat chronic rhinosinusitis (CRS). However, the effects of antibiotics on the microbiome and secreted proteome remain unknown in regard to CRS.We analyzed the effects of antibiotics on the nasal secreted proteome inthe context of CRS using data-independent acq...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018960 | Pride
Human Crs Nasal fluids Data independent acqusition 
TranscriptomicsTranscriptome profiling of nasal polyp derived human IL17RB positive and negative T-helper cells
Background: Chronic rhinosinusitis with nasal polyposis (CRSwNP) in western countries is characterized by eosinophilia, IgE production and Th2 cytokine expression. Type 2 innate lymphoid cells (ILC2) from polyps produce IL-5 and IL-13 in response to IL-25 and IL-33 although the relevance of this axi...
ORGANISM(S): Homo sapiens 
2015-12-22 | E-GEOD-70898 | biostudies-arrayexpress
TranscriptomicsDynamics of Virus-specific CD8+ T cells in the Human Nasal Cavity
The goal of this experiment is to compare the transcriptomic profile of CD8+ T cells isolated from the nasal cavity and whole blood at two different state, baseline and CD3/28 activated. This will allow us to characterise the unique features of CD8+ T cells in the nasal cavity. We isolated CD8+CD4...
ORGANISM(S): Homo sapiens 
2025-08-23 | E-MTAB-15436 | biostudies-arrayexpress
ProteomicsIn-depth proteomic analysis of nasal secretions from chronic rhinosinusitis and nasal polyps
Considering the complex and multifarious features of Chronic rhinosinusitis (CRS) including immunologic patterns, novel modalities are needed to reflect clinical and pathophysiological endotypes beyond nasal polyps.We aimed to investigate the proteome of nasal secretions on filter paper from CRS pat...
ORGANISM(S): Homo sapiens (Human) 
2019-07-29 | PXD013330 | Pride
Nasal secretion Chronic rhinosinusitis Nasal polyps Label-free quantification 
Transcriptomics3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product (nasal epithelial cells-microRNA dataset).
In vitro toxicology approaches have evolved, from a focus on the molecular changes within a cell to understanding of toxicity-related mechanisms that simulate the in vivo environment. The recent development of three dimensional (3-D) organotypic nasal epithelial culture models offer a physiologicall...
ORGANISM(S): Homo sapiens 
2018-04-01 | E-MTAB-6613 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat nasal respiratory and olfactory epithelium
The nasal epithelium is an important target site for chemically-induced toxicity and carcinogenicity. Human epidemiological investigations and experimental laboratory animal studies show that the nasal olfactory epithelium is selectively damaged by inhalation exposure to several chemicals, includin...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5019 | biostudies-arrayexpress
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