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TranscriptomicsA global analysis of tandem 3'UTRs in eosinophilic chronic rhinosinusitis with nasal polyps
Background: Alternative polyadenylation (APA) is emerging as a widespread mechanism of gene regulation. The usage of APA sites allows a single gene to encode multiple mRNA transcripts with different 3'-untranslated region (3'UTR) lengths. Many disease processes reflect the importance of the regulati...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-39957 | biostudies-arrayexpress
ProteomicsIn-depth proteomic analysis of nasal fluids from patients with chronic rhinosinusitis and nasal polyps by data-independent acqusition
Antibiotics are commonly prescribed to treat chronic rhinosinusitis (CRS). However, the effects of antibiotics on the microbiome and secreted proteome remain unknown in regard to CRS.We analyzed the effects of antibiotics on the nasal secreted proteome inthe context of CRS using data-independent acq...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018960 | Pride
Human Crs Nasal fluids Data independent acqusition 
TranscriptomicsTranscriptome profiling of nasal polyp derived human IL17RB positive and negative T-helper cells
Background: Chronic rhinosinusitis with nasal polyposis (CRSwNP) in western countries is characterized by eosinophilia, IgE production and Th2 cytokine expression. Type 2 innate lymphoid cells (ILC2) from polyps produce IL-5 and IL-13 in response to IL-25 and IL-33 although the relevance of this axi...
ORGANISM(S): Homo sapiens 
2015-12-22 | E-GEOD-70898 | biostudies-arrayexpress
ProteomicsIn-depth proteomic analysis of nasal secretions from chronic rhinosinusitis and nasal polyps
Considering the complex and multifarious features of Chronic rhinosinusitis (CRS) including immunologic patterns, novel modalities are needed to reflect clinical and pathophysiological endotypes beyond nasal polyps.We aimed to investigate the proteome of nasal secretions on filter paper from CRS pat...
ORGANISM(S): Homo sapiens (Human) 
2019-07-29 | PXD013330 | Pride
Nasal secretion Chronic rhinosinusitis Nasal polyps Label-free quantification 
TranscriptomicsTotal RNAseq of human healthy control inferior turbinate and glucocorticoid-treated, NSAID-exacerbated respiratory disease (N-ERD) nasal polyp nasal brushings
NSAID-exacerbated respiratory disease (N-ERD) represents a particularly severe endotype of chronic rhinosinusitis with nasal polyps (CRSwNP), which affects around 10-16% of CRSwNP patients. N-ERD is characterized by severe and refractory nasal polyposis, bronchial asthma and intolerance to non-stero...
ORGANISM(S): Homo sapiens 
2020-06-30 | E-MTAB-7962 | biostudies-arrayexpress
ProteomicsProteomic analysis of mucus from chronic rhinosinusitis patients with or without nasal polyps
Patients with chronic rhinosinusitis (CRS) have abnormal immune responses triggered by a variety of infectious agents, airborne toxins and fungi. Respiratory epithelial cells serve as relay stations capable of amplifying or augmenting cues received from external stimuli to nearby immune cells locate...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079984 | MassIVE
ProteomicsProteomic analysis of mucus from chronic rhinosinusitis patients with or without nasal polyps
Patients with chronic rhinosinusitis (CRS) have abnormal immune responses triggered by a variety of infectious agents, airborne toxins and fungi. Respiratory epithelial cells serve as relay stations capable of amplifying or augmenting cues received from external stimuli to nearby immune cells locate...
ORGANISM(S): Homo sapiens (Human) 
2016-05-26 | PXD004144 | Pride
Mucus Nasal mucus Human Lc-ms/ms 
GenomicsTranscriptomic profiling of chronic rhinosinusitis with nasal polyps
Transcriptomic profiling of chronic rhinosinusitis with nasal polyps
PRJNA1494473 | ENA
TranscriptomicsExon Array Analysis of Asthmatic Chronic Rhinosinusitis with Nasal Polyps
Asthmatic chronic rhinosinusitis with nasal polyps (aCRSwNP) is a common disruptive eosinophilic disease. Therefore, we sought to identify gene expression changes in nasosinus inflamed mucosa and adjacent polyp tissue from subjects with aCRSwNP. Twelve asthmatic chronic rhinosinusitis (aCRS) subjec...
ORGANISM(S): Homo sapiens 
2010-08-12 | E-GEOD-23552 | biostudies-arrayexpress
GenomicsChronic Rhinosinusitis with Nasal Polyps
Role of tissue remodeling and reduced antimicrobial activity in recurrent chronic rhinosinusitis with nasal polyps
PRJEB88945 | ENA
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