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UnknownIntracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury.
Not available
S-EPMC2860706 | biostudies-literature
MetabolomicsHERPES SIMPLEX VIRUS TYPE 1 IMPAIRS DENDRITIC CELL FUNCTION BY REMODELLING NEUTRAL LIPID METABOLISM AND INDUCING LIPID DROPLET ACCUMULATION
Herpes simplex virus type 1 (HSV-1) infects dendritic cells (DCs), professional antigen-presenting cells that initiate and regulate host antiviral responses. HSV-1 infects DCs limiting their maturation, migration to draining lymph nodes and T cell activation capacity, ultimately promotes their apopt...
2025-04-03 | MTBLS5163 | MetaboLights
UnknownProtective Effects of Human Liver Stem Cell-Derived Extracellular Vesicles in a Mouse Model of Hepatic Ischemia-Reperfusion Injury.
Not available
S-EPMC8036187 | biostudies-literature
ProteomicsPig myocardial tissue quantitative proteomics
Proteomics study of the anthracycline-induced cardiotoxicity in in pigs with pre-existing left ventricular (LV) pressure overload. Large White pigs (2-month-old males and females) were used to induce LV pressure overload via supravalvular aortic stenosis (or sham operation). After 4 months, animals ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2026-02-05 | PXD056684 | Pride
Myocardial tissue Lc-msms Tmt10plex isobaric labeling Quantitative proteomics Pig 
ProteomicsEED and IgG (as control) co-immunoprecipitation of wild type embryonic stem cells (ESCs), with 3 biological replicates per condition.
DNA and Histone-3 Lysine 27 methylation typically function as repressive modifications and operate within distinct genomic compartments. In mammals, the majority of the genome is kept in a DNA methylated state, whereas the Polycomb Repressive Complexes regulate the unmethylated CpG-rich promoters o...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-06 | PXD039719 | Pride
Epigenetic regulation Mouse embryonic stem cells Eed Polycomb 
ProteomicsDynamic antagonism between key repressive pathways maintains the placental epigenome -1
DNA and Histone-3 Lysine 27 methylation typically function as repressive modifications and operate within distinct genomic compartments. In mammals, the majority of the genome is kept in a DNA methylated state, whereas the Polycomb Repressive Complexes regulate the unmethylated CpG-rich promoters o...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-27 | PXD039611 | Pride
Mouse trophoblast stem cells Epigenetic regulation Eed Polycomb 
ProteomicsRIT1 oncoproteins escape LZTR1-mediated proteolysis
These data accompany our publication "RIT1 oncoproteins escape LZTR1-mediated proteolysis" (Castel P., et al. Science, 2019). Experiment 1: Identification of LZTR1 as an interacting partner of RIT1 Q Exactive Plus P20161208-02 FLAG GFP P20161208-03 FLAG RIT1 LTQ Orbitrap Velos ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-02-14 | MSV000083444 | MassIVE
UnknownAstegolimab or Efmarodocokin Alfa in Patients With Severe COVID-19 Pneumonia: A Randomized, Phase 2 Trial.
Not available
S-EPMC9749945 | biostudies-literature
ProteomicsLoss of stromal Gαq fosters oral cancer progression
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive cancer, with limited therapeutic options and a high mortality rate, primarily due to metastasis and recurrence. Tumor-stroma interactions, and namely cancer-associated fibroblasts (CAFs), are pivotal in shaping HNSCC progression. C...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-27 | PXD061641 | Pride
Human Exosome Oral cancer Stromal gαq 
UnknownPreexposure chemoprophylaxis for HIV prevention in men who have sex with men.
Not available
S-EPMC3079639 | biostudies-literature
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