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ProteomicsCharacterizing the secretome of EGFR mutant lung adenocarcinoma
Lung cancer is the leading cause of cancer related death worldwide, mainly due to the late stage of disease at the time of diagnosis. Non-invasive biomarkers are needed to supplement existing screening methods to enable earlier detection and increased patient survival. This is critical to EGFR-drive...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD045328 | Pride
Lung adenocarcinoma Secretome 
ProteomicsThe CASP3 Prodomain Regulates Human Cell Survival and Proliferation
CASPASE-3 (CASP3) is well known for its proteolytic function that mediates multiple key cell death-initiated processes and other related cellular processes. However, the possibility that CASP3 may also possess important additional non-catalytic functions in mammalian cells has remained largely unexp...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD045234 | Pride
Casp3 Mammary cells 
ProteomicsProteomic analysis of archival breast cancer clinical specimens identifies biological subtypes with distinct survival outcomes
Despite the advancement of genomic classification of breast cancer, current clinical tests and treatment decisions are commonly based on protein level information. Formalin-fixed paraffin-embedded (FFPE) tissue specimens are widely available and can be directly linked to extended clinical outcomes. ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD024322 | Pride
Proteomics Tmt Ffpe Breast cancer 
ProteomicsThe Inhibitory Receptor Siglec-8 Interacts with FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation
Immunomodulation of mast cell (MC) activity is warranted in allergic and inflammatory diseases where MCs have a central role in pathogenesis. Targeting Siglec-8, an inhibitory receptor on MCs and eosinophils, has shown promising activity in preclinical and clinical studies. While the intracellular p...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-21 | PXD030820 | Pride
Siglec-8 Mast cell 
ProteomicsWhole proteome analysis of mesonephric-derived cancers describes new potential biomarkers
Mesonephric carcinomas (ME) and Female Adnexal Tumors of probable Wolffian Origin (FATWO) are thought to derive from remnants of the Wolffian/mesonephric ducts – anlages of the male reproductive tract. Mesonephric-like carcinomas (MLC) show identical morphology to ME of the cervix, but occur in the ...
ORGANISM(S): Homo sapiens (Human) 
2020-11-02 | PXD020879 | Pride
Tmt Mesonephric 
ProteomicsProteomic profiling identifies muscle-invasive bladder cancers with distinct biology and responses to platinum-based chemotherapy
Platinum-based neoadjuvant chemotherapy (NAC) prior to radical cystectomy is the preferred treatment for muscle-invasive bladder cancer (MIBC) despite modest survival benefit and significant associated toxicities. Here, we profiled the global proteome of MIBC tumours pre- and post-NAC treatment usin...
ORGANISM(S): Homo sapiens (Human) 
2025-02-11 | PXD049435 | Pride
Bladder cancer Mibc 
ProteomicsThe proteome of clear cell ovarian carcinoma
Clear cell ovarian carcinoma (CCOC) is the second most common subtype of epithelial ovarian carcinoma. Late stage CCOC is not responsive to gold-standard chemotherapy and result in suboptimal outcome for patients. In-depth molecular insight is urgently needed to stratify the disease and drive therap...
ORGANISM(S): Homo sapiens (Human) 
2022-09-02 | PXD032355 | Pride
Ovarian carcinoma Tmt Clear cell 
ProteomicsUncovering biological heterogeneity in endometrial carcinoma molecular subtypes by proteomic analysis
While endometrial cancer (EC) has an overall favorable prognosis, some patients do poorly and may benefit from refinements of current classification systems. Molecular classification stratifies ECs into four prognostic groups: POLEmut, MMRd (mismatch repair deficient), p53abn, and NSMP (no specific ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD057700 | Pride
Ffpe Endometrial carcinoma Tmt 
ProteomicsChanges in the tumor microenvironment mark transition from serous borderline tumor to low grade serous carcinoma
Low grade serous ovarian cancer (LGSC) is a rare subtype of ovarian cancer, characterized by a slow growth rate, resistance to current treatment regimens, multiple recurrences and poor survival. LGSC arise from serous borderline tumor (SBT), however the mechanism of transformation is poorly understo...
ORGANISM(S): Homo sapiens (Human) 
2024-08-15 | PXD046360 | Pride
Tmt Ovarian cancer Serous borderline tumor 
ProteomicsClass I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis
Outcomes for metastatic bone sarcomas, Ewing sarcoma and osteosarcoma, are dismal and remain unchanged for decades. Oxidative stress attenuates melanoma metastasis, and melanoma cells must reduce oxidative stress to metastasize. To explore this in sarcomas, we screened libraries of approved compound...
ORGANISM(S): Homo sapiens (Human) 
2019-10-28 | PXD014827 | Pride
Yb-1 Ms275 Sarcoma Hdac 
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