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TranscriptomicsmRNAseq analysis of Nkx2.2, Nkx6.1, and Olig2 overexpression in neural progenitors
Nkx2.2, Nkx6.1, and Olig2 repressors were overexpressed, singly or in combination, in in vitro-derived mouse neural progenitors to identify thier repression targets Overexpression study to identify genes repressed by Nkx2.2, Nkx6.1, and Olig2 in neural progenitors
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-65457 | biostudies-arrayexpress
ProteomicsProteomic signatures of schizophrenia-sourced iPSC-derived neural progenitors and neurons
Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspects of its multifactorial complexity are still unknown, and some are accepted to be an early developmental deficiency with a more specifically neurodevelopmental origin. Understan...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD026593 | Pride
Neuron Scz Neural cell Disease Hnpc Organoid Ips Proteome 
GenomicsSox2 ChIP-seq in hindbrain and spinal cord neural progenitors differentiated from mouse embryonic stem cells
Sox2 is a key determinant of neural cell identity, expressed in neural progenitors from anterior to posterior levels. We asked if the occupancy of this factor changes in neural progenitors with different axial identities. To this end, we performed the directed differentiation of mouse embryonic stem...
ORGANISM(S): Mus musculus 
2018-08-27 | E-MTAB-6348 | biostudies-arrayexpress
ProteomicsEml1-associated proteins in mouse neural progenitors
Echinoderm microtubule (MT)-associated protein-like 1 (Eml1) is mutated in the HeCo mouse, which exhibits subcortical band heterotopia (SBH), a developmental malformation of the cerebral cortex. EML1 mutations are also found in human patients affected by severe ribbon-like heterotopia, associated wi...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-19 | PXD006837 | Pride
Neural progenitors Mouse Microtubules Eml1 Cortical development 
TranscriptomicsTranscriptional responses to Sonic Hedgehog pathway stimulation in in vitro derived neural progenitors
The objective of this study was to identify genes regulated by Sonic Hedgehog pathway stimulation in neural progenitors. Paired (parallel culture) triplicates of neuralized embryoid body cultures with and without Shh pathway stimulation (Ag1.3-treatment)
ORGANISM(S): Mus musculus 
2012-12-15 | E-GEOD-42565 | biostudies-arrayexpress
TranscriptomicsATAC-seq on ESCs undergoing directed differentiation towards defined neural fates
We have used ATAC-seq to track cell state changes that occur during the differentiation of mouse embryonic stem cells to defined neural progenitor fates. We have performed ATAC-seq every 24 hours in cells en route to 3 distinct neural progenitors fates, anterior, hindbrain and spinal cord. This has ...
ORGANISM(S): Mus musculus 
2018-08-27 | E-MTAB-6337 | biostudies-arrayexpress
TranscriptomicsIdentification and Expression Patterns of Novel Long Non-Coding RNAs in Neural Progenitors of the Developing Mammalian Cortex
Long non-coding (lnc)RNAs play key roles in many biological processes. Elucidating the function of lncRNAs in cell type specification during organ development requires knowledge about their expression in individual progenitor types rather than in whole tissues. To achieve this during cortical develo...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-65487 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonic stem cells during differentiation to more restricted neural progenitors
The purpose of this study was to examine global gene expression during the differentiation of human embryonic stem cells to more restricted neural progenitors. We developed an adherent differentiation protocol with completely defined media that produced 2 distinct classes of neuroepithelia based on...
ORGANISM(S): Homo sapiens 
2007-03-09 | E-SMDB-3806 | biostudies-arrayexpress
TranscriptomicsProspective Identification, Isolation, and Profiling of a Telomerase-Expressing Subpopulation of Human Neural Stem Cells, using sox2 Enhancer-Directed Fluorescence-Activated Cell Sorting
Sox2 is expressed by neural stem and progenitor cells, and a sox2 enhancer identifies these cells in the forebrains of both fetal and adult transgenic mouse reporters. We found that an adenovirus encoding EGFP placed under the regulatory control of a 0.4 kb sox2 core enhancer selectively identified ...
ORGANISM(S): Homo sapiens 
2011-02-25 | E-GEOD-27505 | biostudies-arrayexpress
GenomicsNext Generation Sequencing Facilities Quantitative analysis of hiPSC derived neural stem cells, early neural progenitors, neural progenitors and neural progenitors after exposure to Idebenone and Bezafibrate Transcriptomes
Next Generation Sequencing Facilities Quantitative analysis of hiPSC derived neural stem cells, early neural progenitors, neural progenitors and neural progenitors after exposure to Idebenone and Bezafibrate Transcriptomes
PRJNA686679 | ENA
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