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MetabolomicsOxygen-induced pathological angiogenesis promotes intense lipid synthesis and remodeling in the retina

The retina is a notable tissue with high metabolic needs which relies on specialized vascular networks to protect the neural retina while maintaining constant supplies of oxygen, nutrients and dietary essential fatty acids. Here we analyzed the lipidome of the mouse retina under healthy and patho...

2023-05-09 | MTBLS6965 | MetaboLights
TranscriptomicsEndothelin2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis
Endothelin signaling is required for neural crest migration and homeostatic regulation of blood pressure. Here we report that constitutive over-expression of Endothelin-2 (Edn2) in the mouse retina perturbs vascular development by inhibiting endothelial cell (EC) migration across the retinal surfac...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-50059 | biostudies-arrayexpress
ProteomicsA proteogenomic atlas of the human neural retina
The human neural retina is enriched for alternative splicing, and it is estimated that more than 10% of variants associated with inherited retinal diseases (IRDs) alter splicing. Previous research mainly used short-read RNA-sequencing techniques to investigate retina-specific splicing and splicing f...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD045187 | Pride
Human Pacbio long-read rna-sequencing Proteogenomics Neural retina Msfragger Dda-pasef 
GenomicsOtx2 ChIP-seq in the adult mouse Retinal Pigmented Epithelium (RPE) and neural retina
Otx2 has been shown to be non cell autonomously required for photoreceptor cell survival in the adult mouse RPE. This study aims to identify Otx2 DNA binding profile in both RPE and neural retina to i) identify direct targets of Otx2 in the RPE ii) compare Otx2 binding profile in neural retina and R...
ORGANISM(S): Mus musculus 
2014-01-15 | E-GEOD-54084 | biostudies-arrayexpress
ProteomicsThe proteome of normal human retina
The retina is a delicate tissue that detects light, converts photochemical energy into neural signals, and transmits the signals to the visual cortex of the brain. A detailed protein inventory of the proteome of the normal human eye may provide a foundation for new investigations into both the physi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-26 | MSV000079537 | MassIVE
TranscriptomicsEffects of Aging and Anatomic Location on Gene Expression in Human Retina
Objective: To determine the effects of age and topographic location on gene expression in human neural retina. Methods: Macular and peripheral neural retina RNA were isolated from human donor eyes for DNA microarray and quantitative RTPCR analyses. Results: Total RNA from human donor retina preserve...
ORGANISM(S): Homo sapiens 
2015-05-27 | E-GEOD-32614 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse developing and mature Nrl -/- retina against wild type controls
The rod photoreceptor-specific neural retina leucine zipper protein Nrl is essential for rod differentiation and plays a critical role in regulating gene expression. In the mouse retina, rods account for 97% of the photoreceptors; however, in the absence of Nrl (Nrl-/-), no rods are present and a co...
ORGANISM(S): Mus musculus 
2009-10-30 | E-GEOD-8972 | biostudies-arrayexpress
OtherThe proteome of human retina.
Data from ProteomeXchange, PXD ID: PXD001242. File: KYCzx3yI-6939_8.mgf. Published as part of Proteomics. 2014 Nov 19 . From the Abstract: {{i}} The retina is a delicate tissue that detects light, converts photochemical energy into neural signals, and transmits the signals to the visual cortex of t...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320005063 | GPMDB
Resource Reanalysis 
TranscriptomicsSingle cell RNA-seq of adult human neural retina
To comprehensively profile cell types in the human retina, we performed single cell RNA-sequencing on 20,009 cells obtained post-mortem from three donors and compiled a reference transcriptome atlas. Using unsupervised clustering analysis, we identified 18 transcriptionally distinct clusters represe...
ORGANISM(S): Homo sapiens 
2019-08-21 | E-MTAB-7316 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of zebrafish embryonic retinal pigment epithelium in vivo
Eye development and photoreceptor maintenance requires the retinal pigment epithelium (RPE), a thin layer of cells that underlies the neural retina. Despite its importance, RPE development has not been studied by a genomic approach. A microarray expression profiling methodology was established in th...
ORGANISM(S): Danio rerio 
2008-06-13 | E-GEOD-5048 | biostudies-arrayexpress
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