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ProteomicsDiscovery of novel markers for identifying cognitive decline from neuron-derived exosomes
Alzheimer’s disease (AD), the predominant cause of late-life dementia, has a multifactorial etiology. Since there are few therapeutic options for symptomatic AD, research is increasingly focused on the identification of pre-symptomatic biomarkers. Recently, evaluation of neuron-derived exosomal mark...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027561 | Pride
Mci Proteomics Neuron derived exosome 
ProteomicsNeuron-Derived Exosomes as a tool for the study of Parkinson disease: a rapid workflow for morphology, miRNA and proteomic characterization.Neuron-Derived Exosomes as a tool for the study of Parkinson disease: a rapid workflow for morphology, miRNA and proteomic characterization.Neuron-Derived Exosomes as a tool for the study of Parkinson disease: a rapid workflow for morphology, miRNA and proteomic characterization.
Neuron derived exosomes have been enriched from plasma using L1CAM antigen. Vesicles were enriched from plasma of Parkinson Disease patients and controls. The NDE morphology was observed by transmission electron microscope (TEM). miRNA-155 content was studied both in PD-NDE and control-NDE. LC-MS/MS...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020794 | Pride
Proteomics Parkinson disease Neuron derived exosomes Plasma L1cam 
GenomicsNeuron-derived exosome from plasma show altered miRNA cargo as a function of antidepressant drug response.
Neuron-derived exosome from plasma show altered miRNA cargo as a function of antidepressant drug response.
PRJNA625058 | ENA
UnknownIntestinal Epithelial Cell Exosome Launches IL-1β-Mediated Neuron Injury in Sepsis-Associated Encephalopathy.
Not available
S-EPMC8801738 | biostudies-literature
ProteomicsGrowth factor-mediated regulation of neuronal exosome release depends on VAMP3/cellubrevin
Extracellular vesicles (EVs) are small membrane-derived vesicles that shuttle proteins or nucleic acids between glia and neurons, thereby promoting neuronal survival and plasticity in the CNS. Exosomes are small EVs (40-150 nm) that are derived from multi-vesicular bodies (MVBs) of the endo-lysosoma...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-02-06 | PXD014401 | Pride
Vamp3 Rat Neurons Exosome 
UnknownThe Diagnostic Value of Exosome-Derived Biomarkers in Alzheimer's Disease and Mild Cognitive Impairment: A Meta-Analysis.
Not available
S-EPMC7957006 | biostudies-literature
UnknownSurface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood-brain barrier penetration.
Not available
S-EPMC6547645 | biostudies-literature
UnknownDetection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.
Not available
S-EPMC5877524 | biostudies-literature
MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
UnknownMutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis.
Not available
S-EPMC3668729 | biostudies-literature
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