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GenomicsThe LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease
The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease
PRJNA640370 | ENA
ProteomicsDifferential Proteomic Landscape of Plasma Neuron-Derived Extracellular Vesicles in Parkinson’s Disease with and without RBD
Parkinson’s disease (PD) is increasingly recognized as a heterogeneous disorder, with rapid eye movement sleep behavior disorder (RBD) serving as a key prodromal marker for a distinct, aggressive subtype. This study investigates the plasma neuron-derived extracellular vesicle (EV) proteome to deline...
ORGANISM(S): Homo sapiens (Human) 
2026-08-27 | PXD076025 | Pride
Neuron-derived extracellular vesicle Α-synuclein Lipid metabolism Hetrogenity L1cam Rapid eye movement sleep behavior disorder (rbd) Proteomics Extracellular matrix remodeling Subtype stratification Precision medicine Parkinson’s disease Biomarkers 
UnknownThe LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson's disease.
Not available
S-EPMC8514240 | biostudies-literature
ProteomicsExtracellular vesicles are crucial mediators in orchestrating brain development and disease
Extracellular vesicles have been the center of many studies focusing on neuron-to-neuron communication while the role of EVs in progenitor-to-neuron and -astrocyte communication occurring during brain development has not been systematically investigated. In this project, we focus on the physiologica...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD028438 | Pride
Cerebral organoids Neurodevelopmental disease Lc-msms Brain development Extracellular vesicles Cstb 
TranscriptomicsThe LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease
Astrocytes are essential cells of the central nervous system, characterized by dynamic relationships with neurons that range from functional metabolic interactions and regulation of neuronal firing activities, to the release of neurotrophic and neuroprotective factors. In Parkinson’s disease (PD), d...
ORGANISM(S): Homo sapiens 
2021-10-06 | GSE152768 | GEO
UnknownBrain-derived extracellular vesicle microRNAs in Lewy body and Alzheimer's disease.
Not available
S-EPMC12258949 | biostudies-literature
ProteomicsBrain-derived extracellular vesicle proteomics reveals neuroprotection induced by the ARB candesartan in Parkinson’s disease patients
In models of Parkinson’s disease (PD), angiotensin-II type-1 receptor (AT1) blockers (ARBs) mitigated the vulnerability ofdopaminergic neurons, which aligns with recent transcriptomic studies of human brains showing increased susceptibility ofdopaminergic neurons with high AGTR1 expression, and with...
ORGANISM(S): Homo sapiens (Human) 
2025-12-06 | PXD063198 | Pride
UnknownNeuron-derived extracellular vesicles in plasma present a potential non-invasive biomarker for Huntingtin protein and RNA assessment in Huntington disease.
Not available
S-EPMC12330537 | biostudies-literature
UnknownAstrocyte-neuron crosstalk through extracellular vesicle-shuttled miRNA-382-5p promotes traumatic brain injury.
Not available
S-EPMC11671591 | biostudies-literature
UnknownPathogenic Extracellular Vesicle (EV) Signaling in Amyotrophic Lateral Sclerosis (ALS).
Not available
S-EPMC9587178 | biostudies-literature
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