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GenomicsNeuronal membrane proteasome-derived peptides modulate neuronal signaling
Neuronal membrane proteasome-derived peptides modulate neuronal signaling
PRJNA944718 | ENA
ProteomicsAn Abundance of Free Proteasomal Regulatory (19S) Particles Regulate Neuronal Synapses Independent of the Proteasome
The major protein-degradation machine, the proteasome, functions at brain synapses and regulates long-term information storage. Here we found that the two essential subcomplexes of the proteasome, the regulatory (19S) and catalytic (20S) particles that assemble to recognize and degrade substrates, w...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-11-26 | PXD037893 | Pride
K48 Synapse Neurons Neuronal proteasome 19s K63 Pull-down Immunoprecipitation Proteasome Ubiquitin 
ProteomicsAn Abundance of Free Proteasomal Regulatory (19S) Particles Regulate Neuronal Synapses Independent of the Proteasome
The major protein-degradation machine, the proteasome, functions at brain synapses and regulates long-term information storage. Here we found that the two essential subcomplexes of the proteasome, the regulatory (19S) and catalytic (20S) particles that assemble to recognize and degrade substrates, w...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-11-26 | PXD041161 | Pride
K48 In-gel digest Synapse Neurons Neuronal proteasome Native page 19s K63 Proteasome Ubiquitin 
TranscriptomicsGlobal transcriptomic profiling of lactacystin-mediated neuronal death
Inhibition of proteasome degradation pathway has been implicated in neuronal cell death leading to neurodegenerative diseases such as ParkinsonM-bM-^@M-^Ys disease and AlzheimerM-bM-^@M-^Ys disease. Pharmacological proteasomal inhibitors such as lactacystin can induce apoptosis in cultured mouse co...
ORGANISM(S): Mus musculus 
2012-01-03 | E-GEOD-22465 | biostudies-arrayexpress
ModelsOuzounoglou2014 - Modeling of alpha-synuclein effects on neuronal homeostasis
Ouzounoglou2014 - Modeling of alpha-synuclein effects on neuronal homeostasis This model is described in the article: In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis. Ouzounoglou E, Kalamatianos D, Emmanouilidou E, Xi...
2024-09-02 | BIOMD0000000559 | BioModels
GenomicsThe Nociceptive Activity of Peripheral Sensory Neurons is Modulated by the Neuronal Membrane Proteasome
The Nociceptive Activity of Peripheral Sensory Neurons is Modulated by the Neuronal Membrane Proteasome
PRJNA1088500 | ENA
ProteomicsActivity-dependent degradation of the nascentome by the neuronal membrane proteosome
Activity-dependent changes in neuronal function require coordinated regulation of the protein synthesis and protein degradation machinery to maintain protein homeostasis, critical to proper neuronal function. However, the biochemical evidence for this balance and coordination remains poorly understo...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-11 | PXD009920 | Pride
Nascentome Degradation Neuronal-specific 20s membrane proteosome complex Translation 
UnknownA mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function.
Not available
S-EPMC5383508 | biostudies-literature
TranscriptomicsNeuronal membrane proteasome-derived peptides modulate neuronal signaling
The novel neuroproteasome is localized to the neuronal plasma membrane to degrade intracellular proteins into peptides that are released to the extracellular space. Selective inhibition of this neuronal membrane proteasome (NMP) complex ceased the release of peptides and rapidly attenuated neuronal ...
ORGANISM(S): Mus musculus 
2023-10-15 | GSE227371 | GEO
GenomicsNeuronal activity promotes nuclear proteasome-mediated degradation of PDCD4 to regulate activity-dependent transcription in neurons
Neuronal activity promotes nuclear proteasome-mediated degradation of PDCD4 to regulate activity-dependent transcription in neurons
PRJNA685031 | ENA
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