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ProteomicsThe 19S RP-associated deubiquitylation downstream of AP-3β disassembles heat-induced stress granules in plants
To survive under adverse conditions, plants form stress granules (SGs) to temporally store mRNA and halt translation as a primary response. Dysregulation in SG disassembly can have detrimental effects on plant survival after stress release, yet the underlying mechanism remains poorly understood in p...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-01-24 | PXD054299 | Pride
Stress granules (sgs)  ap-3β  19s rp  deubiquitylation  non-proteolytic function 
Proteomics19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism
During regulated protein degradation, the 26S proteasome recognizes ubiquitinated substrates through its 19S particle and then degrades them in its 20S enzymatic core. Despite this close interdependency between proteasome subunits, we demonstrate that knockouts from different proteasome subcomplexes...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD065357 | Pride
Proteasome Mitosis Spindle Degradation Kinesin Ubiquitin 
ProteomicsThe adaptor protein AP-3β disassembles heat-induced stress granules via 19S RP-associated deubiquitylation in Arabidopsis
To survive under adverse conditions, plants form stress granules (SGs) to temporally store mRNA and halt translation as a primary response. Dysregulation in SG disassembly can have detrimental effects on plant survival after stress release, yet the underlying mechanism remains poorly understood. Usi...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-01-24 | PXD058194 | Pride
Stress granules  ap-3β  tsn1/2  19s rp  deubiquitylation 
ProteomicsAn Abundance of Free Proteasomal Regulatory (19S) Particles Regulate Neuronal Synapses Independent of the Proteasome
The major protein-degradation machine, the proteasome, functions at brain synapses and regulates long-term information storage. Here we found that the two essential subcomplexes of the proteasome, the regulatory (19S) and catalytic (20S) particles that assemble to recognize and degrade substrates, w...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-11-26 | PXD037893 | Pride
K48 Synapse Neurons Neuronal proteasome 19s K63 Pull-down Immunoprecipitation Proteasome Ubiquitin 
ProteomicsAn Abundance of Free Proteasomal Regulatory (19S) Particles Regulate Neuronal Synapses Independent of the Proteasome
The major protein-degradation machine, the proteasome, functions at brain synapses and regulates long-term information storage. Here we found that the two essential subcomplexes of the proteasome, the regulatory (19S) and catalytic (20S) particles that assemble to recognize and degrade substrates, w...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-11-26 | PXD041161 | Pride
K48 In-gel digest Synapse Neurons Neuronal proteasome Native page 19s K63 Proteasome Ubiquitin 
UnknownNonproteolytic roles of 19S ATPases in transcription of CIITApIV genes.
Not available
S-EPMC3953376 | biostudies-literature
Unknown19S proteasome loss causes monopolar spindles through ubiquitin-independent KIF11 degradation.
Not available
S-EPMC11741298 | biostudies-literature
UnknownThe central unit within the 19S regulatory particle of the proteasome.
Not available
S-EPMC2481239 | biostudies-literature
Unknown19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism.
Not available
S-EPMC12432587 | biostudies-literature
UnknownCompromising the 19S proteasome complex protects cells from reduced flux through the proteasome.
Not available
S-EPMC4551903 | biostudies-literature
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