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TranscriptomicsGene expression profiling of B lymphocytes and plasma cells from Waldenstrons macroglobulinemia.
The tumoral clone of Waldenstrons macroglobulinemia (WM) shows a wide morphological heterogeneity which ranges from B-lymphocytes (BL) to plasma cells (PC). By means of genome-wide expression profiling we have been able to identify genes exclusively deregulated in BL and PC from WM, but with a simil...
ORGANISM(S): Homo sapiens 
2007-03-01 | E-GEOD-6691 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of MYC DNA-binding sites in Burkitt's lymphoma
Background: MYC is a transcription factor encoded by the c-MYC gene (thereafter termed MYC). MYC is key transcription factor involved in many central cellular processes including ribosomal biogenesis. MYC is overexpressed in the majority of human tumours including aggressive B-cell lymphoma especial...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-30726 | biostudies-arrayexpress
Transcriptomicsc-myc-3'RR/p53+/- mice lymphomas
c-myc-3'RR mice prone to develop Burkitt lymphoma (BL) were crossed with p53+/- mice in order to obtain c-myc-3'RR/p53+/- mice. These mice develop a wider spectrum of lymphoma including BL, mantle cell lymphoma (MCL) and plasma cell lymphoma (PCL). Transcriptoma analysis of these lymphomas is invest...
ORGANISM(S): Mus musculus 
2012-01-05 | E-GEOD-31814 | biostudies-arrayexpress
TranscriptomicsBurkitt Lymphoma Pathogenesis and Therapeutic Targets from Structural and Functional Genomics
Burkitt lymphoma (BL) can often be cured by intensive chemotherapy, but the toxicity of such therapy precludes its use in the elderly and in patients with endemic BL (eBL) in developing countries, necessitating new strategies. The normal germinal center B cell is the presumed cell of origin for both...
ORGANISM(S): Homo sapiens 
2012-08-16 | E-GEOD-35163 | biostudies-arrayexpress
TranscriptomicsGene expression in primary human B cells sorted according to IL-10 secretion or not after 2 days of activation.
To determine characterize human B cells that express IL-10 on a molecular level, we compared the global gene expression of primary CD19pos B cells secreting IL-10 or not, upon activation with anti-CD40, IL-4 and CpG for 2 days. Human B cells from healthy donors were sorted according to CD19 expressi...
ORGANISM(S): Homo sapiens 
2014-03-24 | E-GEOD-49853 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse BAFF-stimulated B cells
The aim of the study was to illucidate how BAFF mediates B cell survival and growth through the identification of BAFF-regulated genes. Experiment Overall Design: RNA was isolated from unstimulated B cells ("minus") or after 36 hours of treatment with 25 ng/ml of BAFF ("plus"). A fraction of cell ly...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5985 | biostudies-arrayexpress
TranscriptomicsEpstein-Barr virus maintains lymphomas via its miRNAs
EpsteinM-bM-^@M-^PBarr virus (EBV) has evolved exquisite controls over its host cells, human B lymphocytes, not only directing these cells during latency to proliferate and thereby expand the pool of infected cells, but also to survive and thereby persist for the lifetime of the infected individual....
ORGANISM(S): Homo sapiens 
2013-04-30 | E-GEOD-44769 | biostudies-arrayexpress
TranscriptomicsAntibody repertoire RNA-seq throughout key stages of mouse B-cell development (pre-B-cells, naive B cells, plasma cells)
We sought to investigate the extent of genetic and antigen-driven predetermination of antibody repertoires throughout B-cell development (pre-B cells, naive B cells, plasma cells). To this end, we used (i) an inbred model organism (mouse, C57BL/6J) to quantify genetic predetermination and (ii) cohor...
ORGANISM(S): Mus musculus 
2017-03-28 | E-MTAB-5349 | biostudies-arrayexpress
ProteomicsDeciphering the interplay of aflatoxin B1 and Epstein-Barr virus on the histone landscape in Burkitt Lymphoma cells
Aflatoxin B1 (AFB1), a potent dietary carcinogen, and Epstein-Barr virus (EBV), an oncogenic virus, are both implicated in cancer development, particularly in endemic regions. However, the combined effects of AFB1 exposure and EBV infection on the epigenetic landscape remain poorly understood. This ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-23 | PXD060719 | Pride
Human Epstein-barr virus Aflatoxin b1 Hptms Burkitt lymphoma cells Lc-ms/ms 
ProteomicsProteome profiling of Akkermansia muciniphila, Bifidobacterium longum, and Bifidobacterium breve in different nutrient environments
To understand how glycans influence the growth of probiotic strains in monocultures and communities, we characterized the growth and perform proteome profiling of 3 major probiotics, A. muciniphila (AM) BAA-835, B. breve (BB) JCM1192, and B. longum (BL) JCM1217 in monocultures and co-cultures grown ...
ORGANISM(S): Akkermansia muciniphila ATCC BAA-835 
2025-09-24 | PXD060954 | Pride
Arabinoxylan Bifidobacterium breve Co-culture Probiotics Bifidobacterium longum Akkermansia muciniphila Mucin 
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