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UnknownBEAM: a randomized phase II study evaluating the activity of bevacizumab in combination with carboplatin plus paclitaxel in patients with previously untreated advanced melanoma.
Not available
S-EPMC4669379 | biostudies-literature
UnknownSARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19.
Not available
S-EPMC9278252 | biostudies-literature
ProteomicsEndothelial cell-derived apoptotic bodies modulate innate and adaptive immune responses during inflammation
Endothelial cells (ECs) act as gatekeepers and signalling hubs that coordinate communication between blood vessels and surrounding tissues by regulating vascular tone, immune responses and numerous other physiological processes. During vascular inflammation commonly associated with aging, atheroscle...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD067178 | Pride
Human Lc-msms Endothelial Inflammation apoptosis 
ProteomicsMouse osteoclast homogenates nLC-ESI-MS/MS - WT vs Slc37a2 KO
To survey the proteomic differences between WT and Slc37a2 knockout osteoclasts at the whole cell and secretory lysosome levels, we used superparamagnetic iron oxide nanoparticles (SPIONs) to enrich for these endo-lysosomal-related organelles from murine osteoclast cultures. Briefly, large scale mur...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-25 | PXD037910 | Pride
Lysosome Lro Mouse Spion Osteoclast Secretory lysosome 
ProteomicsMouse osteoclast secretory lysosomes nLC-ESI-MS/MS
To survey the proteome of osteoclast secretory lysosomes, we used superparamagnetic iron oxide nanoparticles (SPIONs) to enrich for these endo-lysosomal-related organelles from murine osteoclast cultures. Briefly, large scale murine bone marrow monocyte (BMM)-derived osteoclast cultures were ‘pulsed...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-25 | PXD037006 | Pride
Lysosome Lro Mouse Spion Osteoclast Secretory lysosome 
ProteomicsMouse osteoclast secretory lysosomes nLC-ESI-MS/MS - WT vs Slc37a2 KO
To survey the proteome of osteoclast secretory lysosomes, we used superparamagnetic iron oxide nanoparticles (SPIONs) to enrich for these endo-lysosomal-related organelles from murine osteoclast cultures. Briefly, large scale murine bone marrow monocyte (BMM)-derived osteoclast cultures were ‘pulsed...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-25 | PXD037813 | Pride
Lysosome Lro Mouse Spion Osteoclast Secretory lysosome 
UnknownEphA2- and HDAC-Targeted Combination Therapy in Endometrial Cancer.
Not available
S-EPMC10816153 | biostudies-literature
TranscriptomicsAnthrax Lethal Toxin-Inducd Gene Expression Changes in Mouse Lung
Enhanced susceptibility of A/J mice to death by systemic anthrax lethal toxin (LeTx) administration compared to the C57BL/6 strain was observed. In this study we investigated whether systemic exposure of mice to LeTx would induce gene expression changes associated with vascular/capillary leakage in ...
ORGANISM(S): Mus musculus 
2011-09-06 | E-GEOD-28554 | biostudies-arrayexpress
ProteomicsSkeletal Muscle TFEB Signaling Promotes Central Nervous System Function and Reduces Neuroinflammation during Aging and Neurodegenerative Disease
Skeletal muscle has recently arisen as a novel regulator of Central Nervous System (CNS) function and aging, secreting bioactive molecules known as myokines with metabolism-modifying functions in targeted tissues, including the CNS. Here we report the generation of a novel transgenic mouse with enha...
ORGANISM(S): Mus Musculus 
2023-12-06 | PXD045241 | panorama
UnknownT cell-dependent bispecific antibodies alter organ-specific endothelial cell - T cell interaction
Not available
S-SCDT-10_15252-EMBR_202255532 | biostudies-other
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