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MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
MetabolomicsMechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach
S-Sulfocysteine (SSC), a bioavailable L-cysteine derivative (Cys), is known to be taken up and metabolized in Chinese hamster ovary (CHO) cells used to produce novel therapeutic biological entities. To gain a deeper mechanistic insight into the SSC biological activity and metabolization, a multi-omi...
2024-08-08 | MTBLS7424 | MetaboLights
UnknownA Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias <i>In Vivo</i>.
Not available
S-EPMC5856643 | biostudies-literature
UnknownA new species of the genus <i>Scincella</i> Mittleman, 1950 (Squamata, Scincidae) from Guizhou Province, southwest China.
Not available
S-EPMC12603643 | biostudies-literature
TranscriptomicsNew role for the (pro)renin receptor in T cell development
The (pro)renin receptor (PRR) was originally thought to be important in regulating blood pressure via the renin-angiotensin system (RAS), however it is emerging that PRR is instead generally essential for cellular development via its involvement in Wnt signalling. Here, we have specifically deleted ...
ORGANISM(S): Mus musculus 
2015-07-01 | E-MTAB-3568 | biostudies-arrayexpress
TranscriptomicsGene expression data of Lsd1fl/fl and Lsd1fl/fl Mx1Cre CD150+ CD48- lin- c-Kit+ Sca-1+ LT-HSCs
We discovered that mice that lack Lsd1 in hematopoietic cells were exhibited increased frequencies of CD150+ CD48- lin- c-Kit+ Sca-1+ LT-HSCs, but completely lacked the lin- c-Kit+ Sca-1- myeloid progenitor compartment. To determine the genes altered by Lsd1-loss, CD150+ CD48- lin- c-Kit+ Sca-1+ LT-...
ORGANISM(S): Mus musculus 
2013-06-25 | E-GEOD-40284 | biostudies-arrayexpress
UnknownTranscription factor IRF-5 regulates lipid metabolism and mitochondrial function in murine CD8<sup>+</sup> T-cells during viral infection.
Not available
S-EPMC12316916 | biostudies-literature
ProteomicsThe CRL3gigaxonin ubiquitin ligase-USP15 pathway governs the destruction of neurofilament proteins
Giant axonal neuropathy (GAN) is caused by mutations in the GAN gene encoding for gigaxonin (GIG), which functions as an adaptor of the CUL3-RBX1-GIG (CRL3GIG) E3 ubiquitin ligase complex. The pathological hallmark of GAN is characterized by the accumulation of densely packed neurofilaments (NFs) in...
ORGANISM(S): Homo sapiens (Human) 
2025-11-06 | PXD042592 | Pride
Usp15 Gan Gigaxonin Neurofilament 
UnknownCD4<sup>+</sup>CD8α<sup>low</sup> T Cell Clonal Expansion Dependent on Costimulation in Patients With Rheumatoid Arthritis.
Not available
S-EPMC11605268 | biostudies-literature
MetabolomicsDIATAGeR: Triacylglycerol Annotation of Data-Independent Acquisition based Lipidomics

Triacylglycerols (TGs) are the most abundant lipids in the human body and the primary source of energy storage. Altered TGs are implicated in metabolic syndrome and detailed structural information may provide novel insights into diseases pathology. TGs are comprised of three fatty acyls with vari...

2025-03-04 | MTBLS11927 | MetaboLights
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