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ProteomicsStructure of transcription preinitiation complex engaged with the +1 nucleosome
The preinitiation complex (PIC) assembles on promoters of protein-coding genes to position RNA polymerase II (Pol II) for transcription initiation. Previous structural studies revealed the PIC on different promoters, but did not address how the PIC assembles in chromatin. In the yeast Saccharomyces ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-03-11 | PXD029840 | Pride
+1 nucleosome Transcription Preinitiation complex Tfiih 
ProteomicsIdentification of a novel class of cytotoxic granules as origin of supramolecular attack particles in T lymphocytes
Cytotoxic T lymphocytes (CTL) kill malignant and infected cells via cytotoxic proteins such as granzyme B (GzmB) that are released into the immunological synapse in the form of ~110 nm supramolecular attack particles (SMAPs). However, it is not known where SMAPs are stored in the cell and how they a...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD025055 | Pride
Exocytosis Proteomics Snare proteins Immunological synapse Cytotoxic granules Single core granules Supramolecular attack particles Total internal reflection fluorescence microscopy Correlative light and electron microscopy Multi core granules 
ProteomicsAllosteric transcription stimulation by super elongation complex
The super elongation complex (SEC) contains the positive transcription elongation factor b (P-TEFb) and a subcomplex, ELL2-EAF1, which stimulates transcription elongation by RNA polymerase II (Pol II). Here we report the cryo-EM structure of ELL2-EAF1 bound to a Pol II elongation complex at 2.8 Å re...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2021-07-15 | PXD024457 | Pride
Super elongation complex Stimulation of transcription elongation Transcription Eaf1 P-tefb Pol ii protrusion Rna polymerase ii Ell2 Tfiif 
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