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ProteomicsCombined proteomics/genomics approach reveals proteomic changes of mature virions as a novel poxvirus adaption mechanism
DNA viruses, like poxviruses, possess a highly stable genome, suggesting adaption of virus particles to specific cell types is not restricted to genomic changes. Cowpox viruses (CPXV) are zoonotic poxviruses with an extraordinary broad host range, demonstrating their adaptive potential in vivo. To e...
ORGANISM(S): Cowpox virus (CPV) 
2017-11-14 | PXD007567 | Pride
Poxvirus Adaption Cowpox virus Lc-ms/ms 
ProteomicsTriggered offset fragmentation allows massively multiplexed target profiling on quadrupole-orbitrap mass spectrometers
Parallel reaction monitoring (PRM) on quadrupole-orbitrap mass spectrometers has a limited multiplexing capacity which depends heavily on the reproducibility of peptide retention times. To overcome these limitations, we aimed to establish a data acquisition mode that allows retention-time-independen...
ORGANISM(S): Candida albicans (Yeast) Homo sapiens (Human) 
2020-06-19 | PXD017778 | Pride
Prm Multiplexing Targeted proteomics Quantification Lc-ms/ms 
ProteomicsComparison of the Cowpox Virus and Vaccinia Virus Mature Virion Proteome: Analysis of the species- and strain-specific Proteome
Cowpox virus (CPXV) causes most zoonotic orthopoxvirus (OPV) infections in Europe and Northern as well as Central Asia. The virus has the broadest host range of OPV and is transmitted to humans from rodents and other wild or domestic animals. Increasing numbers of human CPXV infections in a populati...
ORGANISM(S): Orthopoxvirus 
2015-11-16 | PXD003013 | Pride
Ltq-orbitrap Virion proteome Orthopoxvirus 
ProteomicsCowpox virus proteomics reveals massive ubiquitination and proteasomal degradation of viral proteins but stable virus cores
The ubiquitin-proteasome system (UPS) is essential for replication of Orthopoxviruses (OPV) like vaccinia and cowpox virus (CPXV). Although several proteome studies identified ubiquitin as part of OPV particles, distinct modification sites are largely unknown. Moreover, the UPS plays a key role in p...
ORGANISM(S): Cowpox virus Cowpox virus (CPV) 
2018-02-07 | PXD006426 | Pride
Ubiquitination Viral proteomics Orthopoxvirus 
TranscriptomicsComparison of host cell gene expression in cowpox, monkeypox or vaccinia virus infected cells reveals virus-specific regulation of immune response genes
Orthopoxviruses are large DNA viruses which can cause disease in numerous host species. Even though the eradication of variola virus - the causative agent of human smallpox M-bM-^@M-^S succeeded, with the end of vaccinations several other orthopoxviruses emerged as potential threat to human health. ...
ORGANISM(S): Homo sapiens 
2012-04-14 | E-GEOD-36854 | biostudies-arrayexpress
UnknownCerebral Protection in TAVR-Can We Do Without? A Real-World All-Comer Intention-to-Treat Study-Impact on Stroke Rate, Length of Hospital Stay, and Twelve-Month Mortality.
Not available
S-EPMC8878932 | biostudies-literature
ProteomicsDeep time-course proteomics of SARS-CoV and SARS-CoV-2 infected human lung epithelial cells (Calu-3) reveals strong induction of interferon-stimulated gene (ISG) expression by SARS-CoV-2 in contrast to SARS-CoV
In the present study, we used data-independent acquisition mass spectrometry (DIA-MS) to analyse the protein expression in Calu-3 cells infected with SARS-CoV and SARS-CoV-2 over the time-course of 24 hours. About 8400 proteins were identified, from which about 90% could be quantified across the exp...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome-related coronavirus 
2022-01-20 | PXD024883 | Pride
Sars-cov-2 Sars-cov Calu-3 Human lung cells 
UnknownInvasive Hemodynamic Assessment and Procedural Success of Transcatheter Tricuspid Valve Repair-Important Factors for Right Ventricular Remodeling and Outcome.
Not available
S-EPMC9200997 | biostudies-literature
UnknownClinical Impact of Pre-Procedural Percutaneous Coronary Intervention in Low- and Intermediate-Risk Transcatheter Aortic Valve Replacement Recipients.
Not available
S-EPMC8304453 | biostudies-literature
UnknownMultiorgan Dysfunction and its Association With Congestion and Outcome in Aortic Stenosis Treated With TAVI.
Not available
S-EPMC11780109 | biostudies-literature
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