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ProteomicsGlobal profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa
Spermatozoa acquire fertilization potential during passage through a highly specialized region of the extra-testicular ductal system known as the epididymis. In the absence of de novo gene transcription or protein translation, this functional transformation is extrinsically driven via the exchange o...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-21 | PXD028834 | Pride
Rhoa Proteomics Mass spectrometry Acrosome reaction Sperm maturation Epididymis Male fertility Sperm proteome Spermatozoa 
ProteomicsPhosphoproteomic analysis of the adaption of epididymal epithelial cells to corticosterone challenge
Background: The epididymis has long been of interest owing to its role in promoting the functional maturation of the male germline. More recent evidence has also implicated the epididymis as an important sensory tissue responsible for remodeling of the sperm epigenome, both under physiological condi...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-08 | PXD028789 | Pride
Proteomics Cellular signaling Stress response Corticosterone Sperm maturation Phosphoproteomics Epididymis 
ProteomicsProteomic analysis of koala (Phascolarctos cinereus) spermatozoa and prostatic bodies
The aims of this study were to investigate the proteome of koala (Phascolarctos cinereus) spermatozoa and that of the prostatic bodies with which they form intimate contact at the moment of ejaculation. For this purpose, spermatozoa and prostatic bodies were obtained from four adult male koala by el...
ORGANISM(S): Phascolarctos cinereus (Koala) 
2021-08-23 | PXD024250 | Pride
Spermatozoa Koala Prostatic bodies Proteomics 
ProteomicsCrocodile Sperm Proteome
In a reproductive strategy that is considered unique to the mammalian lineage, spermatozoa must undergo a series of physiological changes, termed capacitation, in the female reproductive tract prior to developing their capacity to fertilize an ovum. Here, we have employed a comparative proteomic str...
ORGANISM(S): Crocodylus Porosus (ncbitaxon:8502) 
2018-04-08 | MSV000082258 | MassIVE
ProteomicsThe reproductive toxicant acrylamide modulates the mouse epididymal proteome to drive alterations to the sperm epigenome and dysregulate embryo development
Paternal exposure to a range of environmental and lifestyle factors elicits distinct changes to the sperm sncRNA profile; modifications that have significant post-fertilization consequences. Despite this knowledge, there remains limited mechanistic understanding of how paternal exposures effect the ...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-07 | PXD022865 | Pride
Small non-protein-coding rna Acrylamide Embryo development Sperm maturation Proteome Epididymis Spermatozoa 
ProteomicsMouse Sperm TMT MCP
Mouse Sperm Proteomic Profiling - University of Newcastle - Dr. Matt Dun
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-06-24 | MSV000082497 | MassIVE
TranscriptomicsIsolation and next generation sequencing of epididymal extracellular vesicles reveals segmental patterns of miRNA expression and a potential mechanism for modification of the sperm epigenome.
Interest in the sperm epigenome continues to grow in view of the realization that it is vulnerable to dynamic modifications arising from a variety of paternal environment exposures and that this legacy can serve as an important determinant of intergenerational inheritance. It has been postulated tha...
ORGANISM(S): Mus musculus 
2016-08-25 | E-GEOD-79500 | biostudies-arrayexpress
TranscriptomicsThe microRNA signature of mouse spermatozoa is dynamically modified during epididymal maturation
In recent years considerable effort has been devoted to understanding the epigenetic control of sperm development leading to an increased appreciation of the importance of RNA interference pathways, and in particular microRNAs (miRNAs), as key regulators of spermatogenesis and epididymal maturation....
ORGANISM(S): Mus musculus 
2015-08-05 | E-GEOD-70198 | biostudies-arrayexpress
ProteomicsThe reproductive toxicant acrylamide modulates the mouse epididymal proteome to drive alterations to the sperm epigenome and dysregulate embryo development.
Paternal exposure to a range of environmental and lifestyle factors elicits distinct changes to the sperm sncRNA profile; modifications that have significant post-fertilization consequences. Despite this knowledge, there remains limited mechanistic understanding of how paternal exposures effect the ...
ORGANISM(S): Mus Musculus 
2021-10-08 | PXD022876 | panorama
UnknownStratified analyses refine association between TLR7 rare variants and severe COVID-19.
Not available
S-EPMC11320601 | biostudies-literature
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