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ProteomicsNitro-oleic acid in a HFpEF two-hit mouse model of high fat diet and L-NAME
Heart failure is a disease with increasing prevalence, while present treatment options, especially for heart failure with preserved ejection fraction (HFpEF), are inadequate. Hypertension and obesity-related metabolic dysfunctions are important risk factors for HFpEF development and progression. Nit...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-18 | PXD058165 | Pride
Hfpef Mouse Heart Hfd No2-oa 
UnknownNitro-Oleic Acid (NO2-OA) Release Enhances Regional Angiogenesis in a Rat Abdominal Wall Defect Model.
Not available
S-EPMC5984564 | biostudies-literature
ProteomicsNitroalkylated proteins in Arabidopsis thaliana development identified by LC-MS/MS
Nitro-fatty acids (NO2-FAs) act as potent electrophiles due to the presence of a nitro group attached to the double bond in their carbon chain. This chemical configuration enables them to react with nucleophilic residues in proteins, specifically cysteines, histidines and lysines, via a process know...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-09-29 | PXD060471 | Pride
TranscriptomicsNitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice
Lack of non-invasive diagnostic tools and effective therapies constitute two of the major hurdles for a bona fide treatment against non-alcoholic steatohepatitis (NASH) progression and/or regression of nonalcoholic fatty liver disease (NAFLD). Nitro-oleic acid (OA-NO2) has been proven effective in m...
ORGANISM(S): Mus musculus 
2019-02-08 | GSE126204 | GEO
GenomicsNitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice
Nitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice
PRJNA521305 | ENA
UnknownNitro-Oleic Acid in Seeds and Differently Developed Seedlings of Brassica napus L.
Not available
S-EPMC7154869 | biostudies-literature
UnknownRedox properties and human serum albumin binding of nitro-oleic acid.
Not available
S-EPMC6554544 | biostudies-literature
ProteomicsEndogenous anti-tumorigenic nitro-fatty acids are a novel type of direct and potent inhibitor of the 26S proteasome
Nitro-fatty acids (NFAs) are endogenous lipid mediators causing a broad spectrum of anti-inflammatory effects by covalent modification of key proteins within inflammatory signaling pathways. Their potential as anti-tumorigenic therapeutics has recently been demonstrated in animal models of solid tum...
ORGANISM(S): Homo sapiens (Human) 
2024-03-26 | PXD041458 | Pride
Nitroalkylation Caco2 26s proteasome Lc-ms/ms 
UnknownNitro-oleic acid triggers ROS production via NADPH oxidase activation in plants: A pharmacological approach.
Not available
S-EPMC7153499 | biostudies-literature
UnknownElectrophilic nitro-fatty acids suppress allergic contact dermatitis in mice.
Not available
S-EPMC5352476 | biostudies-literature
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