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ProteomicsDiversity in pervasive translation. A new translational landscape of yeast.
Pervasive translation is a widespread phenomenon that plays an important role in de novo gene birth; however, its underlying mechanisms remain unclear. Based on multiple Ribosome Profiling datasets, we investigated the translational landscape of coding and noncoding regions of yeast. Therefore, we d...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-09-04 | PXD040766 | Pride
Genome evolution Mass spectrometry Non-canonical translation signals De novo coding products Noncoding genome Pervasive translation 
ProteomicsHuman mitochondria require mtRF1 for translation termination at non-canonical stop codons
Mitochondrial translation system highly diverged from its bacterial counterpart. This includes deviation from the universal genetic code, with AGA and AGG having no cognate tRNAs in human mitochondria. Their locations at the end of COX1 and ND6 open reading frames, respectively, suggests they functi...
ORGANISM(S): Homo sapiens (Human) 
2022-11-16 | PXD034342 | Pride
Mtrf1 Tmt Mitochondria Translation 
TranscriptomicsRibosome profiling of Mycobacterium tuberculosis under nutrient starvation
We have performed parallel ribosome profiling and RNA sequencing to determine which mRNAs are being translated during exponential growth and following 24 hours of nutrient starvation in the human pathogen Mycobacterium tuberculosis.
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2021-02-02 | E-MTAB-8835 | biostudies-arrayexpress
UnknownThe ribosome profiling landscape of yeast reveals a high diversity in pervasive translation.
Not available
S-EPMC11472626 | biostudies-literature
UnknownMultiplexed genomic encoding of non-canonical amino acids for labeling large complexes.
Not available
S-EPMC7982790 | biostudies-literature
ProteomicsNeuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
Learning and memory require activity-induced changes in dendritic translation, but which messenger RNAs (mRNAs) are involved and how they are regulated are unclear. Here, to monitor how depolarization impacts local dendritic biology, we employed a dendritically-targeted proximity labeling approach, ...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-02 | PXD050222 | Pride
Neuron Rna localization Localized translation 
UnknownOn the Track of the Missing tRNA Genes: A Source of Non-Canonical Functions?
Not available
S-EPMC8007984 | biostudies-literature
ProteomicsCue-induced modulation of eIF2α-eIF2Bε underlies axonal translation up-regulation in neural wiring
Local protein synthesis is rapidly regulated by extrinsic signals during neural wiring but the translational control mechanisms remain elusive. Here, we show that the guidance cue Sema3A, but not Slit1, elicits precise spatiotemporal control of the phosphorylation of the translation initiation facto...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-01-02 | PXD009250 | Pride
Axon Psilac Neuroproteomics 
UnknownA snapshot of translation in Mycobacterium tuberculosis during exponential growth and nutrient starvation revealed by ribosome profiling.
Not available
S-EPMC7856553 | biostudies-literature
TranscriptomicsRibosome profiling of HeLa cells infected with Enterovirus coxsackiepol (strain CVA-13/Flores)
Ribosome profiling of enterovirus infected cells was used to investigate expression of the virus polyprotein and upstream open reading frames. Samples were either pretreated with initiation inhibitor lactimidomycin (LTM) to cause ribosomes to accumulate at initiation sites, or were flash frozen with...
ORGANISM(S): Homo sapiens 
2025-11-26 | E-MTAB-14994 | biostudies-arrayexpress
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