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MetabolomicsPFKFB3-mediated glycolysis boosts fibroblast activation and subsequent kidney fibrosis

Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remain...

2024-03-12 | MTBLS8281 | MetaboLights
ProteomicsComprehensive Proteomic Profiling of Converted Adipocyte-like Cells from Normal Human Dermal Fibroblast using Data-Independent Acquisition Mass Spectrometry (DIA-MS)
We applied direct conversion of normal human dermal fibroblast (NHDF) into adipocyte-like cells using adipogenic cocktail containing IBMX, dexamethasone, insulin, and rosiglitazone and confirmed prominent lipid droplet accumulation in the converted cells for proteomic research
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD050528 | Pride
Adipocyte-like cells Dia-ms Mass spectrometry Proteomics Extracellular proteome Normal human dermal fibroblast Intracellular proteome. 
TranscriptomicsTranscription profiling of human fibroblasts from the stroma of squamous cell carcinoma and normal dermal fibroblasts
Head and neck squamous cancer stromal fibroblasts produce growth factors influencing phenotype of normal human keratinocytes. Epithelial-mesenchymal interaction between stromal fibroblasts and cancer cells influences the functional properties of tumor epithelium including the tumor progression and s...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-MTAB-97 | biostudies-arrayexpress
GenomicsHomo sapiens strain:Normal Human Dermal Fibroblast
Stage-Specific Transcriptomic Signatures Reveal Key Pathways of Human Fibroblast Senescence
PRJDB37596 | ENA
TranscriptomicsMethylation Pattern of Human Dermal Fibroblasts
In this study, we have analyzed DNA methylation changes upon aging of human dermal fibroblasts by using the HumanMethylation27 BeadChip assessing 27,578 unique CpG sites. Cells were isolated from skin samples donated by young (6-23 years) and elderly (60-73 years) patients undergoing surgical interv...
ORGANISM(S): Homo sapiens 
2012-02-14 | E-GEOD-22595 | biostudies-arrayexpress
ProteomicsIgG from systemic sclerosis patients induce a profibrosing and serotype-dependent phenotype in normal dermal fibroblast: a multi-omics study
Autoantibodies (Aab) are frequent in systemic sclerosis (SSc). While recognized as potent biomarkers, their pathogenic role is much debated. This study explored the effect of purified IgG from SSc patients on the phenotype and function of healthy dermal fibroblast (FB) using an innovative multi-omic...
ORGANISM(S): Homo sapiens (Human) 
2022-06-29 | PXD025885 | Pride
Autoantibodies Sensitive proteomic Systemic sclerosis Multi-omics analysis Anti-topoisomerase type i 
TranscriptomicsTranscription profiling of human dermal microvascular endothelial, fibroblast, and glioblastoma cells treated with mycophenolic acid
The effect of Mycophenolic acid on primary isolated human dermal microvascular endothelial (HDMVEC) and fibroblast cells as well as human glioblastoma brain tumor cell line (U87).
ORGANISM(S): Homo sapiens 
2008-06-25 | E-TABM-315 | biostudies-arrayexpress
TranscriptomicsEpidermolysis bullosa associated cutaneous SCC fibroblast expression profiling
Patients with the genetic skin blistering disease recessive dystrophic epidermolysis bullosa (RDEB) develop aggressive cutaneous squamous cell carcinoma (cSCC). Metastasis leading to mortality is greater in RDEB than in other patient groups with cSCC. Here we investigate the dermal component in RDEB...
ORGANISM(S): Homo sapiens 
2012-05-15 | E-GEOD-37738 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human dermal fibroblasts to determine passage dependent gene expression
Human umbilical vein endothelial cells (HUVECs) formed capillary structures when co-cultured with normal human dermal fibroblasts (NHDFs). HUVEC competence and NHDF supportiveness of cord formation were found to be highly cell-passage dependent with the early passage cells forming more angiogenic co...
ORGANISM(S): Homo sapiens 
2008-06-20 | E-GEOD-11418 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human dermal pericytes compared to the remaining dermal cells of neonatal human foreskin
Pericytes derived from skin dermis can substantially enhance the short-term tissue-regenerative capacity of human epidermal cells already committed to differentiation; they also display both phenotypic and functional properties of mesenchymal stem cells. In this microarray analysis, we compared the ...
ORGANISM(S): Homo sapiens 
2009-10-10 | E-GEOD-17014 | biostudies-arrayexpress
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