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TranscriptomicsDifferential Toxicity of Nuclear RNA Foci Versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS
Nuclear RNA foci are often associated with mis-regulation of RNA processing in repeat expansion diseases. Here we report transcriptomic analysis of flies carrying expanded G4C2 repeats, the most common genetic cause of FTD/ALS. By obtaining an average of 32 million reads per library, we show that th...
ORGANISM(S): Drosophila melanogaster 
2015-09-11 | E-GEOD-72771 | biostudies-arrayexpress
TranscriptomicsCLIP-seq of CsrA foci in Enteropathogenic E. coli
The RNA content of the CsrA foci. EPEC (E2348/69 (strain O127:H6)) expressing CsrA-FLAGx3-GFP or wild-type EPEC expressing untagged CsrA (negative control) were grown to OD 0.6 in DMEM and subjected to the foci-enrichment protocol, followed by RNA extraction and library preparation. Six libraries we...
ORGANISM(S): Escherichia coli O127:H6 str. E2348/69 
2025-04-14 | E-MTAB-14951 | biostudies-arrayexpress
UnknownCharacterization of Aes nuclear foci in colorectal cancer cells.
Not available
S-EPMC4882644 | biostudies-literature
TranscriptomicsDifferential Toxicity of Nuclear RNA Foci Versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS
Nuclear RNA foci are often associated with mis-regulation of RNA processing in repeat expansion diseases. Here we report transcriptomic analysis of flies carrying expanded G4C2 repeats, the most common genetic cause of FTD/ALS. By obtaining an average of 32 million reads per library, we show that th...
ORGANISM(S): Drosophila melanogaster 
2015-09-11 | GSE72771 | GEO
TranscriptomicsTargeted degradation of sense and antisense C9orf72 RNA foci as therapy for amyotrophic lateral sclerosis and frontotemporal dementia (Multiplex Analysis of PolyA-linked Sequences)
Purpose: The purpose of this experiment is to identify a C9-ALS/FTD specific genomic profile in fibroblast lines that is distinct from sporadic ALS without C9orf72 expansion and non-neurologic control cells. The study will then evaluate the effect on this identified profile of ASO treatment targetin...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-51684 | biostudies-arrayexpress
ProteomicsProteomics characterization of NTRK1/TrkA signaling in neuroblastoma cells reveals intra-nuclear aggregation of Lamin A/C
Simple Summary: Neuroblastoma (NB) accounts for 15% of all cancer related deaths of children. While amplification of the Myc-N proto-oncogene (MYCN) is a major driver of NB, expression of the neurotrophin receptor, NTRK1/TrkA, has been shown to associate with an excellent outcome. MYCN down-regulate...
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD026876 | Pride
Neuroblastoma Mycn Nuclear foci Trka Ntrk1 
ProteomicsProteomics characterization of NTRK1/TrkA signaling in neuroblastoma cells reveals intra-nuclear aggregation of Lamin A/C
Simple Summary: Neuroblastoma (NB) accounts for 15% of all cancer related deaths of children. While amplification of the Myc-N proto-oncogene (MYCN) is a major driver of NB, expression of the neurotrophin receptor, NTRK1/TrkA, has been shown to associate with an excellent outcome. MYCN down-regulate...
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD026913 | Pride
Neuroblastoma Mycn Nuclear foci Trka Ntrk1 
UnknownTCF4 Triplet Repeat Expansion and Nuclear RNA Foci in Fuchs' Endothelial Corneal Dystrophy.
Not available
S-EPMC4373545 | biostudies-literature
UnknownSp2 localizes to subnuclear foci associated with the nuclear matrix.
Not available
S-EPMC1415311 | biostudies-literature
UnknownNucleoporin foci are stress-sensitive condensates dispensable for C. elegans nuclear pore assembly.
Not available
S-EPMC10308366 | biostudies-literature
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