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ProteomicsNuclear pore complexes interactome dissection
We purified the different types of NPCs in yeast using a differential affinity purification strategy and analyzed their respective compositions and interactomes by mass spectrometry. Therefore, we compared the relative abundancies of specific nuclear factors and NPCs associated factor between all po...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-13 | PXD027872 | Pride
Nuclear pore heterogeneity Affinity purification Mrna maturation 
ProteomicsSelective autophagy degrades nuclear pore complexes
Nuclear pore complexes (NPCs) are giant cylindrical structures embedded into the nuclear envelope and mediate nucleocytoplasmic exchange. NPC longevity has been linked to aging but since they appear to rarely turn over, the underlying mechanisms remain understudied. Here, we show that upon nitrogen ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-13 | PXD011571 | Pride
Autophagy Nuclear pore complexes 
TranscriptomicsInducible repositioning of mouse gene tethering to the inner nuclear membrane
Nuclear compartmentalization appears to play an important role in regulating metazoan genes. While studies on immunoglobulin (Ig) and other loci have correlated positioning at the nuclear lamina with gene repression, the functional consequences of this compartmentalization remain untested. We devise...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10176 | biostudies-arrayexpress
ProteomicsDistinct Basket Nucleoporins roles in Nuclear Pore Function and Gene Expression
Nuclear pore complexes (NPCs) are important for cellular functions beyond nucleocytoplasmic trafficking, including genome organization and gene expression. This multi-faceted nature and the slow turnover of NPC components complicates investigations of how individual nucleoporins act in these diverse...
ORGANISM(S): Homo sapiens (Human) 
2020-06-30 | PXD020075 | Pride
Auxin-inducible degron Human Nuclear pore complex 
ProteomicsRanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion
Nuclear pore complexes (NPCs) enable nucleocytoplasmic transport. While NPCs primarily localize to the nuclear envelope (NE), they also appear in cytoplasmic endoplasmic reticulum (ER) membranes called annulate lamellae (AL). Though discovered in the mid-20th century, AL’s function and biogenesis re...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD073946 | Pride
Nuclear expansion Climp63 (ckap4) G1 Single molecule localization microscopy (smlm) Annulate lamellae Nuclear growth Fg repeats Ranbp2 (nup358) Nuclear pore complex Cytoplasmic nucleoporin foci 
TranscriptomicsThe nuclear pore-associated TREX-2 complex employs the Mediator Med31 submodule as a docking site to regulate gene expression
Nuclear pore complexes (NPCs) influence gene expression besides their established function in nuclear transport. The TREX-2 complex localizes to the NPC basket and affects gene-NPC interactions, transcription and mRNA export. How TREX-2 regulates the gene expression machinery is unknown. Here, we sh...
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-27 | E-GEOD-67431 | biostudies-arrayexpress
UnknownChannel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans.
Not available
S-EPMC8184135 | biostudies-literature
GenomicsA R-loop sensing pathway mediates the relocation of transcribed genes to nuclear pore complexes
A R-loop sensing pathway mediates the relocation of transcribed genes to nuclear pore complexes
PRJNA935257 | ENA
ProteomicsProbing the trypanosome nuclear pore by TurboID proximity labelling
Previous BioID experiments targeting the nucleoporin (NUP) NUP158 and the nuclear transport factor MEX67 indicated (PMID: 36410438; PXD031245) that proximity labelling delivers highly specific interactome data in the confined localisation of the nuclear pore, with a labelling radius well below the s...
ORGANISM(S): Trypanosoma brucei 
2023-12-04 | PXD047268 | Pride
Bioid Trypanosoma brucei Porin Nuclear transport Nuclear pore 
ProteomicsNuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chro atin
The nuclear pore complex (NPC) physically interacts with chromatin and regulates gene expression. The Saccharomyces cerevisiae inner ring nucleoporin Nup170 has been implicated in chromatin organization and the maintenance of gene silencing in subtelomeric regions. To gain insight into how Nup170 re...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-06-13 | PXD041496 | Pride
Nuclear pore complex Subtelomeric gene silencing Nup170 Nucleoporin Ctf18-rfc Pcna 
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