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MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
ModelsTomida2003 - Calcium Oscillatory-induced translocation of nuclear factor of activated T cells
Tomida2003 - NFAT functions Calcium Oscillation This model is described in the article: NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation. Tomida T, Hirose K, Takizawa A, Shibasaki F, Iino M. EMBO J. 2003 Aug; 22(15): 3825-3832 Abstract: ...
2024-09-02 | BIOMD0000000678 | BioModels
TranscriptomicsCytoplasmic Assembly and Selective Nuclear Import of Arabidopsis ARGONAUTE4/siRNA Complexes
Here we profiled small RNAs from whole cell, cytoplasmic and nuclear extracts from three-week-old Arabidopsis seedlings. We unexpectedly found that nuclear functional hc-siRNAs are predominantly present in the cytoplasm. Samples from Arabidopsis thaliana whole cell, cytoplasmic and nuclear extract...
ORGANISM(S): Arabidopsis thaliana 
2012-07-12 | E-GEOD-36500 | biostudies-arrayexpress
ProteomicsPhosphorylated TLR3 nuclear translocation in cancer cell promotes metastasis and chemoresistance
Phosphorylated TLR3 nuclear translocation in cancer cell promotes metastasis and chemoresistance
ORGANISM(S): Homo Sapiens 
PXD064767 |
ProteomicsTargeted dephosphorylation of TFEB promotes its nuclear translocation
Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localised to the cytoplasm. Stressor-mediated reduction of TFEB phosphorylation prom...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD053308 | Pride
Bdpic Ppp2ca Tfeb Adphosphatase Phostac 
ProteomicsTargeted dephosphorylation of TFEB promotes its nuclear translocation
Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localised to the cytoplasm. Stressor-mediated reduction of TFEB phosphorylation prom...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD053311 | Pride
Adphosphotase Dephosphorylation Bdpic Ppp2ca Tfeb Phostac 
GenomicsStress modulates Ahi1-dependent nuclear localization of Ten-Eleven Translocation Protein 2
Stress modulates Ahi1-dependent nuclear localization of Ten-Eleven Translocation Protein 2
PRJNA704360 | ENA
GenomicsDNA Damage-Induced Nuclear STING Translocation Orchestrates Innate Immune Activation and Chromatin Remodeling [ChIP-Seq]
DNA Damage-Induced Nuclear STING Translocation Orchestrates Innate Immune Activation and Chromatin Remodeling [ChIP-Seq]
PRJNA1259940 | ENA
GenomicsPhosphorylated TLR3 nuclear translocation in cancer cell promotes metastasis and chemoresistance
Phosphorylated TLR3 nuclear translocation in cancer cell promotes metastasis and chemoresistance
PRJNA1272840 | ENA
ProteomicsImportin-7 Promotes Tension-Induced Osteogenesis by Regulating RUNX2 Nuclear Translocation during Orthodontic Tooth Movement
Orthodontic tooth movement (OTM) is primarily driven by alveolar bone remodeling, wherein tension-induced osteogenesis plays a central role. Importin7 (IPO7) has been identified as a highly mechanoresponsive nuclear transport receptor (NTR). However, its role in regulating tension-induced osteogenes...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-10-06 | PXD061760 | Pride
Runx2 Mechanotransduction Ipo7 Tooth movement Nuclear translocation Alveolar bone remodeling 
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