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ProteomicsCardioviruses’ leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic
Proteins from unrelated pathogens, including some RNA or DNA viruses and bacteria can recruit and activate cellular p90-ribosomal protein S6 kinases (RSKs) through a common linear motif. Data suggested a model where pathogens' proteins act to dock the recruited RSKs toward specific substrates, which...
ORGANISM(S): Homo sapiens (Human) 
2022-12-08 | PXD034604 | Pride
P90 ribosomal s6 kinases Picornavirus Nucleocytoplasmic traffic Rsk Cardiovirus Phosphorylation Yopm Nucleoporins Linear motifs 
ProteomicsCardiovirus-Mediated PKR Inhibition Results from Nucleocytoplasmic Trafficking Disruption
Protein kinase R (PKR) is a key antiviral kinase activated by binding double-stranded RNA (dsRNA) produced during viral replication. Upon activation, PKR phosphorylates eIF2α, leading to the inhibition of translation and viral replication. However, many viruses have evolved mechanisms to counteract ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD066206 | Pride
Nucleocytoplasmic traffic Pkr Nucleocytoplasmic trafficking disorder (nctd) Cardiovirus Stress granules. Picornavirus Nucleoli Double-stranded rna Eif2ak2 
UnknownThe high risk HPV16 L2 minor capsid protein has multiple transport signals that mediate its nucleocytoplasmic traffic.
Not available
S-EPMC3249505 | biostudies-literature
UnknownPhosphorylation of yeast hexokinase 2 regulates its nucleocytoplasmic shuttling.
Not available
S-EPMC3516761 | biostudies-literature
UnknownExportin-mediated nucleocytoplasmic transport maintains Pch2 homeostasis during meiosis.
Not available
S-EPMC10688877 | biostudies-literature
UnknownKaryopherin-mediated nucleocytoplasmic transport.
Not available
S-EPMC10101760 | biostudies-literature
UnknownCardiovirus leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic.
Not available
S-EPMC9779665 | biostudies-literature
UnknownRanGAP-mediated nucleocytoplasmic transport of Prospero regulates neural stem cell lifespan in Drosophila larval central brain.
Not available
S-EPMC6351831 | biostudies-literature
UnknownMembrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast.
Not available
S-EPMC2643938 | biostudies-literature
UnknownBrownian dynamics simulation of nucleocytoplasmic transport: a coarse-grained model for the functional state of the nuclear pore complex.
Not available
S-EPMC3107250 | biostudies-literature
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