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ProteomicsSpecialization of the Drosophila nuclear export family protein, Nxf3, for piRNA precursor export
The piRNA pathway is a conserved small RNA-based immune system that protects animal germ cell genomes from the harmful effects of transposon mobilisation. In Drosophila ovaries, most piRNAs originate from dual-strand clusters, which generate piRNAs from both genomic strands. Dual-strand clusters use...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-07-29 | PXD014472 | Pride
Pirna rna export piwi drosophila transposons 
UnknownNxf3 is expressed in Sertoli cells, but is dispensable for spermatogenesis.
Not available
S-EPMC3081378 | biostudies-literature
GenomicsSpecialization of the Drosophila nuclear export family protein, Nxf3, for piRNA precursor export
Specialization of the Drosophila nuclear export family protein, Nxf3, for piRNA precursor export
PRJNA551689 | ENA
UnknownNuclear translocation of CDK5RAP3 regulated by NXF3 promotes the progression of gastric cancer.
Not available
S-EPMC11876495 | biostudies-literature
TranscriptomicsSpecialization of the Drosophila nuclear export family protein, Nxf3, for piRNA precursor export
The piRNA pathway is a conserved small RNA-based immune system that protects animal germ cell genomes from the harmful effects of transposon mobilisation. In Drosophila ovaries, most piRNAs originate from dual-strand clusters, which generate piRNAs from both genomic strands. Dual-strand clusters use...
ORGANISM(S): Drosophila melanogaster 
2019-07-27 | GSE133528 | GEO
TranscriptomicsA heterochromatin-specific RNA export pathway facilitates piRNA production
PIWI-interacting RNAs (piRNAs) guide transposon silencing in animals. The 22-30nt piRNAs are processed in the cytoplasm from long non-coding RNAs. How piRNA precursors, which often lack RNA processing hallmarks of export-competent transcripts, achieve nuclear export is unknown. Here, we uncover the ...
ORGANISM(S): Drosophila melanogaster 
2019-03-28 | GSE126578 | GEO
ProteomicsA novel nuclear RNA export pathway in the human testis – NXT2 is key player and azoospermia candidate gene
In eukaryotic cells, the nucleocytoplasmic export of bulk poly(A)+-mRNAs through the nuclear pore complex is mediated by the ubiquitously expressed NXT1-NXF1 heterodimer. In humans, autosomal NXT1 has an X-chromosomal paralogue called NXT2, which was subject to adaptive selection in primates and exh...
ORGANISM(S): Homo sapiens (Human) 
2025-03-05 | PXD061059 | Pride
Non-obstructive azoospermia Nxf3 Nxf2 Nuclear transport X chromosome Nuclear rna export Male infertility Nxt2 
ProteomicsA novel nuclear RNA export pathway in the human testis – NXT2 is key player and azoospermia candidate gene
In eukaryotic cells, the nucleocytoplasmic export of bulk poly(A)+-mRNAs through the nuclear pore complex is mediated by the ubiquitously expressed NXT1-NXF1 heterodimer. In humans, autosomal NXT1 has an X-chromosomal paralogue called NXT2, which was subject to adaptive selection in primates and exh...
ORGANISM(S): Homo sapiens (Human) 
2024-07-25 | PXD052904 | Pride
Non-obstructive azoospermia Nxf3 Nxf2 Nuclear transport X chromosome Nuclear rna export Male infertility Nxt2 
TranscriptomicsNuclear Export Factor 3 Regulates Localization of Small Nucleolar RNAs
Small nucleolar RNAs (snoRNAs) guide chemical modifications of ribosomal and small nuclear RNAs, functions that are carried out in the nucleus. While most snoRNAs reside in the nucleolus, a growing body of evidence indicates that snoRNAs are also present in the cytoplasm and that snoRNAs move betwee...
ORGANISM(S): Mus musculus 
2017-10-30 | GSE106301 | GEO
UnknownNuclear export factor 3 regulates localization of small nucleolar RNAs.
Not available
S-EPMC5724009 | biostudies-literature
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